The value of preoperative inflammatory markers in patients through total laryngectomy for advanced stage larynx carcinoma

Authors : Mehmet ÇELEBİ, Dursun Mehmet MEHEL, Semih VAN, Seda Nur CİHAN, Doğukan ÖZDEMİR, Abdulkadir ÖZGÜR

Pages : 103-106

View : 100 | Download : 121

Publication Date : 2023-03-18

Article Type : Research Paper

Abstract :The aim of this study is to evaluate the difference between neutrophil, lymphocyte, platelet and RDW insert ignore into journalissuearticles values(red cell distribution width); counts and NLR insert ignore into journalissuearticles values(neutrophil/lymphocyte ratio); and PLR insert ignore into journalissuearticles values(platelet/lymphocyte ratio); between patients who underwent total laryngectomy for advanced stage laryngeal squamous cell carcinoma and healthy control group. The study group consisted of 37 patients insert ignore into journalissuearticles values(36 male, 1 female); who underwent total laryngectomy and bilateral neck dissection for advanced stage laryngeal squamous cell carcinoma between January 2017 and December 2019. As a control group, complete blood count records of 35 healthy individuals who were routinely examined in 2019 within the scope of occupational health and safety were compiled. Blood was collected preoperatively from the patient in the study group. The data obtained from the whole blood counts of the two groups were analyzed statistically by comparing neutrophil, lymphocyte, platelet, RDW, NLR and PLR values. The age difference between the study and control groups was not significant insert ignore into journalissuearticles values(p>0.05);. Neutrophil, platelet and RDW counts were higher in the study group compared to the control group and this difference was statistically significant insert ignore into journalissuearticles values(p=0.001, p=0.035, p=0.001, respectively);. Although the lymphocyte count was high in the study group, the difference was not significant insert ignore into journalissuearticles values(p=0.061);. The difference between NLR and PLR between the two groups was high in the study group and this difference was statistically significant insert ignore into journalissuearticles values(p=0.001, p=0.007, respectively);. Neutrophil, platelet, RDW, NLR, PLR values were significantly higher in patients with advanced stage laryngeal cancer than in the control group. NLR, PLR and RDW values, which can be obtained cheap, simple and rapidly at the diagnosis stage of laryngeal cancers, may be biomarkers in determining prognosis. For this, multicenter, prospective studies are needed.
Keywords : Laryngeal carcinoma, neutrophil lymphocyte ratio, platelet lymphocyte ratio, red cell distribution width

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