Osteopontin, Suppression of Tumorgenicity 2 and Myeloperoxidase Levels in Acute Coronary Syndrome Patients with Fragmented QRS

Authors : Seda Suzan MEMECAN, Tevfik NOYAN, Osman BEKTAŞ

Pages : 225-231

View : 59 | Download : 51

Publication Date : 2023-07-19

Article Type : Research Paper

Abstract :Background/aim: In recent years, studies have focused on new markers to predict the risk of cardiovascular diseases insert ignore into journalissuearticles values(CVD);. There are several studies analyzing biomarkers such as myeloperoxidase insert ignore into journalissuearticles values(MPO);, suppression of tumorgenicity 2 insert ignore into journalissuearticles values(sST2);, and osteopontin insert ignore into journalissuearticles values(OPN); in CVD, however, there are no studies that show their relationship in patients who have fragmented QRS insert ignore into journalissuearticles values(fQRS);. It was aimed to investigate the OPN, sST2, and MPO levels in patients who were diagnosed with the acute coronary syndrome insert ignore into journalissuearticles values(ACS); in the present study. Materials and Methods: Sixty ACS patients and 26 healthy individuals were included in the study. Patients diagnosed ACS were divided into two groups as insert ignore into journalissuearticles values(+);fQRS insert ignore into journalissuearticles values(n=30); and insert ignore into journalissuearticles values(-);fQRS insert ignore into journalissuearticles values(n=30);. Levels of OPN and sST2 were measured by ELISA, and also MPO was measured by colorimetric methods. Results: In ACS patients, serum MPO insert ignore into journalissuearticles values(33.7 U/L);, OPN insert ignore into journalissuearticles values(103.29 ng/mL); and sST2 insert ignore into journalissuearticles values(495.4 pg/mL); levels were found significantly higher than the control group insert ignore into journalissuearticles values(23.14 U/L, 42.65 ng/mL, 344.11 pg/mL, respectively; p<0.01, p<0.01, p<0.05);. However, there were no significant differences between MPO, OPN and sST2 levels in patients with insert ignore into journalissuearticles values(+);fQRS insert ignore into journalissuearticles values(respectively, 32.74 U/L, 101.89 ng/mL and 451.97 pg/mL); and insert ignore into journalissuearticles values(-);fQRS insert ignore into journalissuearticles values(respectively, 34.67 U/L, 104.69 ng/mL, 535.73 pg/mL);. There were also positive correlations between MPO and platelet insert ignore into journalissuearticles values(r=0.376, p<0.05); levels in the insert ignore into journalissuearticles values(+);fQRS group, and sST2 and triglyceride levels in the insert ignore into journalissuearticles values(-);fQRS group. When the diagnostic performances for ACS were examined, the sensitivity of CK-MB, troponin-I, MPO, OPN and sST2 were 83%, 80%, 65%, 85%, 58% and specificity 96%, 100%, 72%, 96%, 80%, respectively. Conclusions: In conclusion, MPO, OPN, and sST2 may be included in the factors that may contribute to the diagnosis and development of ACS. In addition, the discovery of the high diagnostic sensitivity and specificity of OPN in acute coronary syndrome is a new finding obtained in this study.
Keywords : Acute coronary syndrome, osteopontin, sST2, myeleporoxidase

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