Convalescent Plasma Transfusion In Severe Covid-19 Patients Admitted To Intensive Care Unit: A Single Center Study

Authors : Cokorda Agung Wahyu PURNAMASİDHİ, Ida Bagus Yorky BRAHMANTYA, Ni Made Dewi Dian SUKMAWATİ, Anak Agung Ayu Yuli GAYATRİ, I Made Susila UTAMA, I Ketut Agus SOMİA, I Gusti Ngurah Mahaalit ARİBAWA, Ketut Tuti Parwati MERATİ

Pages : 258-263

View : 72 | Download : 93

Publication Date : 2023-07-19

Article Type : Research Paper

Abstract :Initial difficult times of novel coronavirus disease 2019 insert ignore into journalissuearticles values(COVID-19); had clinicians actively seeking appropriate treatment. Convalescent plasma insert ignore into journalissuearticles values(CP); has been studied for treatment of past coronavirus pandemics and was successful with promising efficacy and safety. This study aims to measure the efficacy of convalescent plasma transfusion in severe COVID-19 patients, determined by alleviation of symptoms, improvement in radiologic findings, and laboratory parameters. Cross-sectional study conducted involving 23 severe COVID-19 patients admitted to Udayana University Hospital intensive care unit in 2020. Patients received a minimum 200 mL CP transfusion, dexamethasone, and remdesivir. Data were retrieved from patient’s medical records. Patients mean age was 54.04 years. Mean time from onset of illness to transfusion and length of stay were 11.09 and 16.70 days respectively. No adverse effects were observed during treatment. Twelve patients insert ignore into journalissuearticles values(52.2%); showed alleviation of symptoms and recovered, with 15 days median time from transfusion to recovery. Post-transfusion chest x-ray examination showed varying degrees of absorption of lung lesions in 10 patients insert ignore into journalissuearticles values(43.5%); and was associated with the patient’s outcome insert ignore into journalissuearticles values(p = 0.001);. Significant changes in c-reactive protein insert ignore into journalissuearticles values(p = 0.000); and procalcitonin level insert ignore into journalissuearticles values(p = 0.024); was found as compared to pretransfusion. Despite these findings, almost half the patients insert ignore into journalissuearticles values(47.8%); did not receive benefits from CP transfusion and dead. CP transfusion has shown remarkable improvement in radiologic, inflammatory, and prognostic parameters but was unable to improve patient clinical outcomes and mortality rate.
Keywords : convalescent plasma therapy, COVID 19, critical care, outcome

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