Protective role of Ferulic acid on acrylamide-induced testis toxicity in rats

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Journal of Experimental and Clinical Medicine
Volume:40 Issue:4
Protective role of Ferulic acid on acrylamide-induced testis toxicity in rats

Protective role of Ferulic acid on acrylamide-induced testis toxicity in rats

Authors : Arzu Gezer, Seda Yakut, Nurcan Kılıç Bargutalp, Berrin Tarakcı Gencer

Pages : 740-747

View : 126 | Download : 201

Publication Date : 2024-01-03

Article Type : Research Paper

Abstract :It has become important over the last few years to reduce the detrimental effects of Acrylamide (ACR), which is the carcinogenic substance formed by the exposure of some foods to high temperatures. The present investigation evaluated the defensive effect of ferulic acid (FA) as opposed to toxicity in testis tissue triggered by ACR in male rats. ACR (100 ppm) was administered in drinking water alone or with FA for 30 days orally. This study revealed that treatment with FA could remarkably decrease MDA levels and significantly increase SOD levels in the testicular tissue of the ACR-treated rats. Intaking of FA as a supplement is also supported by increasing FSHR, LHR, and AR sex hormone receptors levels. FA also reduced the harmful effects leading to ACR by decreasing histopathological changes in the testicular tissue. This study demonstrated the probable protective mechanism of FA against testicular toxicity caused by ACR.
Keywords : Acrylamide, Ferulic acid, testis, rat

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