Correlation of tumor necrosis factor-α and sclerostin in bone turnover process of premenopausal women with rheumatoid arthritis

Authors : Malikul Chair, Rudy Hidayat, Sumariyono Sumariyono, Murdani Abdullah, Faisal Parlindungan

Pages : 60-64

View : 56 | Download : 63

Publication Date : 2024-03-29

Article Type : Research Paper

Abstract :Rheumatoid arthritis is associated with systemic bone mass loss due to stimulation of osteoclastogenesis and suppression of osteoblastogenesis through inhibition of Wingless (Wnt)/β catenin canonical and bone morphogenetic proteins (BMP) pathways by sclerostin. Our study assessed the correlation between tumor necrosis factor (TNF)-α and sclerostin with bone resorption markers C-terminal telopeptides of type 1 collagen (CTX) and procollagen type 1 N-terminal propeptide (P1NP) in pre-menopausal rheumatoid arthritis patients. This cross-sectional study involved 38 premenopausal women with RA. Serum TNF-α, sclerostin, P1NP, and CTX level were examined by ELISA method. This study revealed high level of serum CTX (mean 2.74 ng/mL) and a low level of P1NP (median 34.04 pg/mL). There was a significant negative correlation (r = -0.388) between TNF-α and sclerostin levels (p = 0.016), as well as a significant positive correlation (r = 0.362) between TNF-α and P1NP levels (p = 0.026). There was a significant negative correlation between TNF-α and sclerostin, and also a significant positive correlation between TNF-α and P1NP in our study.
Keywords : Bone remodelling, premenopause, rheumatoid arthritis, tumor necrosis factor alpha, Wnt signaling pathway

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