Prognostic Impact of Modified Glasgow Prognostic Score in Patients with Heart Failure with Mildly Reduced Ejection Fraction

Authors : Tahir BEZGİN, Aziz İnan ÇELİK, Ali KARAGÖZ, Nart Zafer BAYTUĞAN, Metin ÇAĞDAŞ, Süleyman KARAKOYUN, Cihangir KAYMAZ

Pages : 6-13

View : 22 | Download : 7

Publication Date : 2022-04-18

Article Type : Research Paper

Abstract :Introduction: Inflammation and malnutrition may trigger heart failure development and progression insert ignore into journalissuearticles values(HF);. However, the relationship of the modified Glasgow prognostic score insert ignore into journalissuearticles values(mGPS);, which is derived from C-reactive protein and albumin with mildly reduced ejection fraction HF insert ignore into journalissuearticles values(HFmrEF);, is not well-known. We aimed to determine whether the modified Glasgow prognostic score insert ignore into journalissuearticles values(mGPS); is helpful for the prediction of all-cause mortality in patients with HFmrEF. Patients and Methods: Patients with HFmrEF admitted to our outpatient clinic between January 2016 and January 2020 were enrolled. All-cause mortality was defined as the primary endpoint. The mGPS was calculated and, its association with overall survival was determined. Results: Data were analyzed for 259 patients. The mGPS≤ 1 in 172 insert ignore into journalissuearticles values(66%);, and 2 in 87 insert ignore into journalissuearticles values(34%); patients, respectively. Higher mGPS was related to worse results of routine biomarkers associated with prognosis, especially NT-proBNP [777 insert ignore into journalissuearticles values(112-4564); pg/mL vs. 350 insert ignore into journalissuearticles values(65-3521); pg/mL, respectively, p< 0.0001);]. In multivariable Cox model, NT-proBNP [1.83 insert ignore into journalissuearticles values(1.32-2.55);, p< 0.0001], mGPS 2 vs. ≤1 [2.43 insert ignore into journalissuearticles values(1.2-4.93);, p= 0.013], and coronary artery disease insert ignore into journalissuearticles values(CAD); [3.15 insert ignore into journalissuearticles values(1.46-6.82);, p= 0.003] were found to be independently associated with all-cause mortality. Conclusion: The immune-nutritional score mGPS predicts mortality during long-term follow-up of patients with HFmrEF. The mGPS might be used for risk status assessment of HFmrEF.
Keywords : Heart failure, ejection fraction, heart