The Relationship Between Levels of Sex Steroids and Coronary Collateral Circulation in Men Patients with Coronary Artery Disease

Authors : Aslan ERDOĞAN, Ender Özgün ÇAKMAK, Ahmet GÜLER, Alev KILIÇGEDİK, Cevat KIRMA

Pages : 33-39

View : 43 | Download : 10

Publication Date : 2022-04-18

Article Type : Research Paper

Abstract :Introduction: Coronary collateral circulation insert ignore into journalissuearticles values(CCC); is a natural bypass system for restoring blood flow, and a well-developed CCC is held to protect myocardial function and improve survival after coronary obstruction as potentially hampering the course of CAD progression. We explored the relationship between the serum levels of sex steroids and CCC. Patients and Methods: A total of 115 males with chronic coronary artery disease who had at least one total coronary artery occlusion were included. Patients were divided into two groups: a well CCC group insert ignore into journalissuearticles values(Rentrop grades 2-3, n= 64); and a poorly developed CCC group insert ignore into journalissuearticles values(Rentrop grades 0-1, n= 51);. Serum levels of total testosterone, free testosterone, sex hormone-binding globulin insert ignore into journalissuearticles values(SHBG);, and dehydroepiandrosterone sulfate insert ignore into journalissuearticles values(DHEA-S); were recorded. A p-value below 0.05 was accepted as significant in all analyses. The confidence interval was accepted as 95%. Results: Serum total testosterone insert ignore into journalissuearticles values(ng/dL; 274.5 ± 57.7 vs. 329 ± 64.8, p< 0.001);, free testosterone insert ignore into journalissuearticles values(pg/mL; 8.2 ± 2.4 vs. 12 ± 3.2, p< 0.001);, DHEAS [µg/dL; 111 insert ignore into journalissuearticles values(58); vs. 160 insert ignore into journalissuearticles values(85.5);, p< 0.001] and SHBG concentrations insert ignore into journalissuearticles values(nmol/L; 29.3 ± 8.6 vs. 33.2 ± 10.2; p= 0.027); were significantly higher in the well coronary collateral group insert ignore into journalissuearticles values(WCG);. According to the results of multiple regression analyses, diabetes [OR= 3.56, CI insert ignore into journalissuearticles values(1.26-3.5); p= 0.017], free testosterone level [OR= 1.57, CI insert ignore into journalissuearticles values(1.26-1.96);, p< 0.001] and total testosterone level [OR= 1.01, CI insert ignore into journalissuearticles values(1.00-1.02);, p= 0.009] were determined to be independent predictors. Conclusion: This study showed that a high level of sex steroids was a predictor of good collateral development in patients with chronic CAD.
Keywords : Coronary artery disease, collateral circulation, sex steroid hormones

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