Triglyceride-Glucose Index Could be Used to Predict Severity of Coronary Artery Ectasia

Authors : Ersan OFLAR, İsmail ÜNĞAN, Cennet YILDIZ, Güngör İlayda BOSTANCI ALP, Büşra MAVİ, Fatma Nihan TURHAN ÇAĞLAR, Alparslan ŞAHİN, Demet ERCİYES

Pages : 34-39

View : 12 | Download : 8

Publication Date : 2023-03-21

Article Type : Research Paper

Abstract :Introduction: Coronary artery ectasia insert ignore into journalissuearticles values(CAE); refers to a 1.5 fold increase in coronary artery diameter compared to the normal segment. Although the underlying pathophysiological mechanism is not fully elucidated, coronary atherosclerosis is thought to play a role in more than half of the cases. Triglyceride glucose insert ignore into journalissuearticles values(TyG); index is an indicator of insulin resistance. In the present study, aimed to evaluated TyG index values in CAE cases and find if a predictive value of TyG index existed. Patients and Methods: Sixty-one patients with CAE insert ignore into journalissuearticles values(study group); and 64 patients with normal coronary arteries insert ignore into journalissuearticles values(control group); were included in the study. TyG index was calculated as ln insert ignore into journalissuearticles values(fasting triglyceride × fasting glucose/2);. Results: There were no differences between the two groups with respect to age, sex, diabetes mellitus prevalence, and biochemical parameters including, white blood cell, platelet, lymphocyte, monocyte counts, hemoglobin, hematocrit, urea, glucose, total cholesterol, high density lipoprotein-cholesterol, triglyceride levels and TyG index value. Twenty-five patients insert ignore into journalissuearticles values(41.0%); had one-vessel involvement, 24 insert ignore into journalissuearticles values(39.3%); patients had twovessel involvement and 12 insert ignore into journalissuearticles values(19.7%); patients had three-vessel involvement. Right coronary artery was the most commonly affected vessel insert ignore into journalissuearticles values(11, 44%);, followed by left anterior descending artery insert ignore into journalissuearticles values(8, 35%);, left main coronary artery insert ignore into journalissuearticles values(4, 16%); and circumflex artery insert ignore into journalissuearticles values(1, 4%);. TyG index was statistically significantly higher in patients who had two/three vessel involvement insert ignore into journalissuearticles values(8.80 ± 0.48 vs 9.14 ± 0.62, p= 0.027);. TyG index had statistically significant correlation with the number of ectatic vessels insert ignore into journalissuearticles values(r= 0.275, p= 0.032);. ROC curve analysis showed that TyG index was useful for the prediction of ectasia severity insert ignore into journalissuearticles values(AUC= 0.653, 95% CI= 0.515-0.792, p= 0.043);. TyG index value of 9.16 had 41.7% sensitivity and 84% specificity for prediction of CAE severity. Conclusion: TyG index, which is easily calculated from biochemical parameters, might be used for the assessment of CAE severity.
Keywords : Triglyceride, glucose, index, coronary arteries, ectasia