Toxicity of polyvinyl alcohols in medicinal chemistry

Authors : Orkun DALYAN, Ömer Faruk ÖZTÜRK, Mehmet PİŞKİN

Pages : 129-135

Doi:10.51354/mjen.918635

View : 14 | Download : 11

Publication Date : 2021-12-06

Article Type : Review Paper

Abstract : Polyvinyl alcohol insert ignore into journalissuearticles values(Chemical Abstracts Service No: 9002-89-5);, biodegradable, biocompatible, water-soluble, odorless, tasteless, transparent, white to creamy granular or powder appearance, and is a synthetic hydroxy polymer used in a broad variety of industrial, trading, medicinal and food implementations. The aim of this review is to back the safety of polyvinyl alcohol qua a coating agent for medicinal chemistry and dietary addition products, considering the current knowledge of polyvinyl alcohol. All available information on polyvinyl alcohol obtained from a comprehensive scientific literature review was seriously evaluated. Orally directed polyvinyl alcohol is comparatively harmless. The safety of polyvinyl alcohol when directed orally is based on: insert ignore into journalissuearticles values(a); Acute oral toxicity LD50 rates are in the range of 14.7–20 g/kg, very low, insert ignore into journalissuearticles values(b); is very poorly absorbed from the digestive system, insert ignore into journalissuearticles values(c); does not accumulate in the body, insert ignore into journalissuearticles values(d); the highest levels of polyvinyl alcohol with no observed adverse effects when directed orally in male and female rats, 5000 mg / kg body weight / day in a 90-day diet survey as the highest dose tested and 5000 mg / kg body weight / day was found in two generation reproductive studies.
Keywords : Polyvinyl alcohol, Toxicity, Medicinal chemistry, Dietary supplement, Coating material