Hirsutism in adolescents: hormonal pattern and ovarian morphology

Authors : Nö TURHAN, B GÜLEKLİ, S SENÖZ, E KUSCU, H ORAL, O GÖKMEN

Pages : 126-130

View : 51 | Download : 8

Publication Date : 1993-12-01

Article Type : Research Paper

Abstract :We have made endocrinologic, symptomatologic and utrasonographic studies in 38 adolescent insert ignore into journalissuearticles values(<18 years of age); patients with the complaint of hirsutism. 15 age-matched subjects were taken as control. The following results were obtained: 1-The causes of hirsutismus in the study group were polycystic ovarian syndrome insert ignore into journalissuearticles values(PCOS); insert ignore into journalissuearticles values(57.9%); insert ignore into journalissuearticles values(n=22);, idiopathic hirsutism insert ignore into journalissuearticles values(IH); insert ignore into journalissuearticles values(39.5%); insert ignore into journalissuearticles values(n=15); and late-onset adrenal hyperplasia insert ignore into journalissuearticles values(LOHD); insert ignore into journalissuearticles values(2.6%); insert ignore into journalissuearticles values(n = 1);. 2- Total testosterone insert ignore into journalissuearticles values(tT);, free testosterone insert ignore into journalissuearticles values(fT);, androstenedione insert ignore into journalissuearticles values(A); and dehidroepiandrostenedione insert ignore into journalissuearticles values(DHEAS); levels were significantly higher in hirsute patients than the controls. 3- There was no statistically significant difference in terms of luteinizing hormone insert ignore into journalissuearticles values(LH);, follicle stimulating hormone insert ignore into journalissuearticles values(FSH);, prolactin insert ignore into journalissuearticles values(PRL);, thyroid stimulating hormone insert ignore into journalissuearticles values(TSH); and 17-hydroxy-progesterone insert ignore into journalissuearticles values(17-OHP); with the study group and the controls. 4-Menstrual irregularities were significantly higher in PCOS group than in the IH group. 5-In PCOS girls the mean ovarian volume and serum estradiol insert ignore into journalissuearticles values(E2); levels were significantly higher than IH group and controls. From the above findings, we suggest that clinical examination, endocrinologic and ultrasonographic investigation must be required in the evaluation of hirsute adolescent girls as considering the heterogenity of the etiology.
Keywords : hirsutism, adolescence, polycystic ovary syndrome, idiopathic hirsutism, late onset adrenal hyperplasia

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