Acute myocardial infarction risk predicted by serum levels of lipoprotein (a) in Turkish population

Authors : Ec CANBULAT, İ TÜRKALP

Pages : 69-73

View : 15 | Download : 10

Publication Date : 1994-04-01

Article Type : Research Paper

Abstract :Lipoprotein insert ignore into journalissuearticles values(a); [Lpinsert ignore into journalissuearticles values(a);J is a macromolecular complex found in human plasma and is composed of 1 low density lipoprotein insert ignore into journalissuearticles values(LDL); particle to which 1 or more molecule of apolipoprotein insert ignore into journalissuearticles values(a); is covalently linked. Elevated levels of Lpinsert ignore into journalissuearticles values(a); have been associated with acute myocardial infarction insert ignore into journalissuearticles values(AMI);. In this study the serum levels of Lpinsert ignore into journalissuearticles values(a); in patients with AMI compared with control subjects in Turkiye was determined. We determined serum levels of Lpinsert ignore into journalissuearticles values(a); in 72 patients insert ignore into journalissuearticles values(47 men and 25 women); with clinically, electrocardiographically and biochemically documented AMI, and in 64 control subjects insert ignore into journalissuearticles values(28 men and 36 women); clinically free of cardiovascular, peripheral or cerebral arterial disease on the basis of history, physical examination and electrocardiographic criteria. Patients with AMI had higher Lpinsert ignore into journalissuearticles values(a); levels than did control subjects insert ignore into journalissuearticles values(33.9 ± 23.9 vs. 14.1 ± 11.1 mg/dl, p<0.0001);. The prevalence of Lpinsert ignore into journalissuearticles values(a); excess insert ignore into journalissuearticles values(defined as >90th percentile of controls); was 55% in patients with AMI. Lpinsert ignore into journalissuearticles values(a); levels were not correlated with other lipid and lipoprotein parameters. Also there was no correlation between serum Lpinsert ignore into journalissuearticles values(a); levels and age and gender of subjects. Our data indicate that Lpinsert ignore into journalissuearticles values(a); is a risk factor for AMI, independent of other lipid and lipoprotein parameters.
Keywords : Lipoprotein a, Lp a, Acute myocardial infarction, AMI, apolipoprotein a,