Results of intravenous immunoglobulin administration in childhood itp

Authors : İ GÖÇMEN, F KARADEMİR, E SARAOĞLU, Z METE, M TUNCER

Pages : 63-66

View : 12 | Download : 10

Publication Date : 1995-03-01

Article Type : Research Paper

Abstract :One chronic and 10 acute ITP patients, admitted to the GATA Haydarpaşa Training Hospital Pediatric Clinic between February 1989 - February 1993 were treated by IVIG in doses of 0.5 g/kg for 5 days. Seven of the patients were female and 4 were male. The mean age was 4.8 years insert ignore into journalissuearticles values(2 months - 9 years);. None of the patients revealed a maternal ITP history. Thrombocyte levels insert ignore into journalissuearticles values(mean 18,090 ± 7,634/mm3); at admission rose sharply within 3 days and reached hemostatic levels on the 5th day insert ignore into journalissuearticles values(mean 231,272 ± 156,770/mm3);. These levels were checked on the 10th, 30th, 150th day and the average was found to be over 150,000/mm3. One patient insert ignore into journalissuearticles values(a 6 year old girl); who gave good response to initial IVIG diagnosed as acute ITP has shown recurrences. These attacks responded to IVIG treatment well and splenectomy was not needed. We observed no reccurences in the other 10 cases. No side effects relating to IVIG were reported. IVIG therapy can be considered as a safe approach to childhood ITP, quickly restoring the hemostatic thrombocyte levels and thus preventing lifethreatening complications such as intracranial hemorrhage in acute ITP and leading to favorable remission periods in chronic ITP.
Keywords : ITP, idiopathic thrombocytopenic purpura, intravenous immunoglobulin, IVIG