HEPATITIS B VIRUS; STRUCTURE, REPLICATION MECHANISM, AND VARIANTS

Authors : SA Özer

Pages : 157-164

View : 13 | Download : 10

Publication Date : 1995-07-01

Article Type : Research Paper

Abstract :The human hepatitis B virus insert ignore into journalissuearticles values(HBV); elicits acute and chronic liver disease in humans and has been linked to hepatocellular carcinoma. The virus is transmitted by perinatal exposure, sexual contact, exposure to blood products and organ/tissue transplantation. HBV is a member of the hepadnavirous family and the viral genome within the HBV particle is a circular, partially double-stranded, relaxed-circular DNA molecule. The infectious particles are called Dane particles and consist of an icosahedral nucleocapsid surrounded by a lipoprotein envelope. The promoter, enhancer, poly- A addition signal and glucocorticoid-responsive element insert ignore into journalissuearticles values(GRE); are signal sexuences which are involved in HBV gene expression. The virus replicates via an RNA pre-genome using covalently closed, circular, double stranded DNA as a transcriptional template. Multiple mutant variants have been identified and characterized at the molecular level with certain clinical syndromes.
Keywords : Hepatitis B virus, HBV replication, HBV variants