Efficacy of N-acetylcysteine in preventing amphotericin B induced acute kidney injury

Authors : Buket Erturk SENGEL, Elif Tukenmez TİGEN, Tayfur TOPTAS, İsik ATAGUNDUZ, Ayse Tulin TUGLULAR, Mehmet Onder ERGÖNÜL, Zekaver ODABASI

Pages : 73-78

Doi:10.5472/MMJoa.2902.02

View : 19 | Download : 14

Publication Date : 2016-04-01

Article Type : Research Paper

Abstract :Objectives: Previously, in an animal study we showed that N-acetylcysteine insert ignore into journalissuearticles values(NAC); could decrease deoxycholate amphotericin B insert ignore into journalissuearticles values(DAmB); induced renal tubular apoptosis. In this clinical study, we aimed to evaluate the efficacy of NAC in preventing acute kidney injury insert ignore into journalissuearticles values(AKI); in febrile neutropenic patients with invasive pulmonary aspergillosis treated with DAmB.Patients and Methods: Thirty-three patients were included in the study. 17 patients were randomly placed into the DAmB group and 16 were randomly placed into the DAmB plus NAC group.Results: The characteristics of patients, durations and cumulative doses of DAmB, concurrent nephrotoxic drugs and basal serum creatinine insert ignore into journalissuearticles values(SCr); levels of patients were similar. Occurrence of a 1.5 fold or greater increase in the concentration of basal SCr and serum electrolytes were observed prospectively. The overall AKI was found in 13 patients insert ignore into journalissuearticles values(76.4%); in DAmB group and 6 patients insert ignore into journalissuearticles values(37.5%); in combination group insert ignore into journalissuearticles values(P = 0.024);. No significant difference was observed in hypokalemia incidence between the groups insert ignore into journalissuearticles values(87.5 % in combination vs. 94.1 % in DAmB only groups);.Conclusion: This clinical pilot study showed that NAC may be a promising anti-oxidant agent to decrease DAmB-induced AKI in febrile neutropenic patients.Keywords: Amphotericin
Keywords : Amfoterisin B, Akut böbrek hasarı, N asetilsistein, Febril nötropeni