A comparison of propofol, alfentanil and midazolam for sedation during spinal anesthesia

Authors : T Umuroğlu, Z Eti, FY Gögüş

Pages : 198-202

View : 31 | Download : 11

Publication Date : 1997-10-01

Article Type : Research Paper

Abstract :Objective: We aimed to compare the efficacy and side effects of propofol, midazolam and alfentanil used for sedation during spinal anesthesia. Methods: Thirty patients aged. 20-70 years, scheduled for inguinal hernia repair, appendectomy or transurethral resection were randomly assigned to three groups insert ignore into journalissuearticles values(n=10);. The patients were given 1.25 mg/kg propofol i.v. in group I, 1.8 |ig/kg alfentanil i.v. in group II and 0.1 mg/kg midazolam i.v. in group III prior performing spinal anesthesia. For maintenance of sedation propofol infusion of 3 mg/kg/h in group I,alfentanil infusion of 40 Jlg/kg/h in group II and midazolam infusion of 0.1 mg/kg/h in group III were started. The infusion rates were adjusted to maintain an appropriate sedation level. In all patients mean arterial pressure insert ignore into journalissuearticles values(MAP);, heart rate insert ignore into journalissuearticles values(HR);, oxygen saturation insert ignore into journalissuearticles values(Sp02);, end tidal carbondioxide insert ignore into journalissuearticles values(ETC02); and respiratory rate insert ignore into journalissuearticles values(RR); were recorded. Results: In propofol group; while MAP and HR decreased significantly after bolus dose, the sedation level 2 was achieved within 5 minutes insert ignore into journalissuearticles values(p<0.05);. In alfentanil group; while HR, MAP and RR decreased and ETC02 increased significantly insert ignore into journalissuearticles values(p<0.05);, the desired sedation level was not achieved. In midazolam group; the sedation level 2 was achieved at 15th minute and MAP, Sp02, HR and RR decreased significantly insert ignore into journalissuearticles values(p<0.05);. Conclusion: We conclude that propofol is the most appropriate agent for sedation during spinal anesthesia.
Keywords : Anesthetics, intravenous, propofol, Hypnotics, benzodiazepines, midazolam, Analgesics, alfentanil, Anesthetic techniques, sedation, spinal