5-AMINOSALICYLIC ACID ASSOCIATED CHRONIC TUBULOINTERSTITIAL NEPHRITIS IN A PATIENT WITH CROHN`S DISEASE

Authors : Mehmet KOÇ, İshak Çetin ÖZENER, Azra BİHORAC, İşın KILIÇASLAN, Emel AKOĞLU

Pages : 226-229

View : 15 | Download : 8

Publication Date : 2016-12-03

Article Type : Other Papers

Abstract :5-Aminosalicyiic acid insert ignore into journalissuearticles values(5-ASA); is the most commonly used drug for the treatment of inflammatory bowel disease insert ignore into journalissuearticles values(IBD);. 5- aminosalicylic acid induced nephrotoxicity has recently been reported. We report a case of female with Crohn`s disease treated with mesalazine for 60 months and sulphasalazine for additional 12 months. The patient presented with loin pain, sterile pyuria and raised serum creatinine. Percutaneous renal biopsy revealed chronic interstitial nephritis and yellow-brown pigment deposition in proximal tubular cells. Steroid treatment was commenced for 4 months and there has been no improvement in renal function. Due to widespread use of mesalazine, and its insidious onset of nephrotoxicity, renal function screening and urinalysis should be routinely performed to detect the toxicity of mesalazine and related drugs. Key Words: Chronic interstitial nephritis, 5- ASA, Sulphasalizine, mesalazine.
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