THE RELATION BETWEEN HUMAN Y CHROMOSOME MICRODELETIONS AND SPERM MORPHOLOGY

Authors : Deniz Sevinç, Ahmet Zehir, Anıl Biricik, Semra Sertyel, Semra Kahraman, İlter Güney

Pages : 227-232

View : 13 | Download : 6

Publication Date : 2016-12-03

Article Type : Research Paper

Abstract :O b je c tiv e : Recent investigations have supported the importance of Y chromosome microdeletions in male infertility. Besides different factors, sperm morphology is also a very important component of the clinical evaluation of male fertility potential. The aim of our study was to understand the relation between Y chromosome microdeletions and sperm morphology in different risk groups. Material and Methods: In this study, 34 infertile men were selected and examined in terms of sperm morphology and Y chromosome microdeletions. Semen analyses of the patients were performed by using Strict criteria and the samples were grouped according to the sperm abnormalities. Peripheral blood samples were examined for Y chromosome microdeletions by a multiplex polymerase chain reaction amplification of sequence-tagged sites insert ignore into journalissuearticles values(STS); of the Y chromosome. R e su lts : The incidence of deletions in the group was 14.7 % insert ignore into journalissuearticles values(5/34);. The rates of Y chromosome microdeletion were 33.3% for megalohead, 33.3% for elongehead, 0% for roundhead, 100% for pinhead, 14.3% for severe teratozoospermia, 33.3% for severe neck abnormalities and 0% for tail-stump Pregnancy could not be obtained from Y chromosome deleted cases. Co nclus io n: It seems that especially patients with sperm head and neck abnormality have increased microdeletion risk. It is suggested that a detailed sperm morphology examination and classification is needed to clarify the Y chromosome deletion-sperm morphology relation. Key Words: Y chromosome microdeletions, Sperm morphology, Male infertility
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