APROTININ IMPROVES Ca2+ - Mg2+ / ATPase LEVELS İN ISCHEMIA-REPERFUSION INJURY1`2

Authors : Selim ISBİR, Rıza DOĞAN, Metin DEMİRCİN, İlhan PAŞAOĞLU

Pages : 23-26

View : 17 | Download : 9

Publication Date : 2016-12-03

Article Type : Research Paper

Abstract :Objective: The aim of this study is to determine the effect of aprotinin, on calcium activated and magnesium dependent adenosine 5’ triphosphatase insert ignore into journalissuearticles values(Ca2+-Mg2+/ATP ase); levels. Methods: Twenty patients who had elective coronary artery bypass grafting insert ignore into journalissuearticles values(CABG); were randomly divided into two groups insert ignore into journalissuearticles values(n= 10, in each);. Group A patients received full dose aprotinin insert ignore into journalissuearticles values(20 000 lU/kg as pretreatment followed by 7500 lU/kg for 6 hours); and Group B patients received normal saline as control group. Erythrocyte membrane Ca2+-Mg2+/ATP ase levels were measured. Results: Ca2*-Mg2+ /ATPase levels were protected in aprotinin group, 807.60+32.62 vs 634.28+22.91 insert ignore into journalissuearticles values(p<0.05); at post-operative 24th hour. insert ignore into journalissuearticles values(p<0.05);. Conclusion: Aprotinin protected the erythocyte membrane Ca2<-Mg2+ ATP/ase from oxidant stress thus it might affect the cell membrane stabilization. Key Words: Aprotinin, Ischemia-Reperfusion injury, Ca2t-Mg2+/ATPase.
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