THE EFFECTS OF ACE-I AND ARB ON PERITONEAL ALBUMIN LOSS AND SERUM ALBUMIN LEVELS IN PERITONEAL DIALYSIS PATIENTS

Authors : Betül ÖĞÜTMEN, Serhan TUĞLULAR, Emel AKOĞLU, Çetin ÖZENER

Pages : 103-106

View : 48 | Download : 13

Publication Date : 2016-12-03

Article Type : Research Paper

Abstract :Objective: Anti-proteinuric effects of angiotensin converting enzyme inhibitors insert ignore into journalissuearticles values(ACE-I); and angiotensin receptor blockers insert ignore into journalissuearticles values(ARB); have been established in various renal diseases. However, the effects of ACE-I and ARB on the permeability of peritoneal membrane are unknown and the effect of ACE-I and ARB use on peritoneal permeability in patients undergoing continuous ambulatory peritoneal dialysis has not been studied. Methods: Fifty non-diabetic patients with high peritoneal permeability, who had been on a regular peritoneal dialysis insert ignore into journalissuearticles values(PD); treatment for at least one year, were included in the study. The patients were prospectively randomized either fosinopril 10 mg/day p.o insert ignore into journalissuearticles values(n=25); insert ignore into journalissuearticles values(group 1); or valsartan 80 mg/day p.o insert ignore into journalissuearticles values(n=25); insert ignore into journalissuearticles values(group 2); for 12 months. All patients received standard 35- cal/kg/day diets with 1,2-g/kg/day protein intake and strict salt restriction. All patients were on standard PD program insert ignore into journalissuearticles values(2 L; 1.36%, 4 exchanges/day);. Annual mean serum albumin level, calculated from the monthly serum albumin level and peritoneal albumin values obtained from the dialysate after 8 hours, dwell on two occasions 6 months apart were measured twice yearly. Results: A significant increase in the serum albumin values, insert ignore into journalissuearticles values(3.68±0.56 g/dl vs. 3.94±0.46 g/dl, p<0.0001); a significant decrease in peritoneal fluid albumin values insert ignore into journalissuearticles values(9.06±2.65 g/dl vs. 7.08±1.43 g/dl, p<0.01); were observed in the ACE-I group following the treatment. While no significant change insert ignore into journalissuearticles values(3.75±0.48 g/dl vs. 3.87±0.37 g/dl, p>0.05); was observed in the serum albumin values, a significant decrease insert ignore into journalissuearticles values(8.62±3.87 g/dl vs. 5.84±2.94 g/dl, p<0.01); was obtained in peritoneal fluid albumin values for the ARB group. Conclusion: At the end of the study a significant decrease was observed in the peritoneal protein values for patients on ACE-I and ARB. Key Words: Peritoneal dialysis, Angiotensin converting enzyme inhibitor, Angiotensin receptor blocker and albumin
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