The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas

Authors : Muhammed Hasan TOPER, Suheyla BOZKURT, Tayfun ELIBOL, Tulin TUGLULAR

Pages : 83-89

Doi:10.5472/marumj.741651

View : 17 | Download : 8

Publication Date : 2020-05-31

Article Type : Research Paper

Abstract :Objective: The cases of diffuse large B-cell lymphoma, insert ignore into journalissuearticles values(DLBCL not otherwise specified insert ignore into journalissuearticles values(NOS);); which immunohistochemically exhibit MYC and BCL2 expressions are defined as double-expressor lymphomas insert ignore into journalissuearticles values(DELs);. This study aimed to assess the prognostic impact of DEL and the expressions of other proteins that may have role in tumorogenesis. Materials and Methods: In this study, 90 tumor samples from patients diagnosed with DLBCL NOS were evaluated retrospectively. Immunoexpressions of MYC, BCL2, activation-induced cytidine deaminase insert ignore into journalissuearticles values(AID);, uracil-DNA glycosylase insert ignore into journalissuearticles values(UNG); and DNA mismatch repair proteins including MLH1, MSH2, MSH6 and PMS2 were analyzed. Result: Eleven cases insert ignore into journalissuearticles values(12.2%); which exhibited ≥40% MYC and ≥50% BCL2 immunexpressions were classified as DEL DLBCL. Patients with MYC positivity displayed lower overall survival rate than MYC negative cases. A trend of lower overall survival was observed in the double-expressor lymphoma group, however, this was not proven to be statistically significant. Significant relationship between AID, UNG and p53 immunexpressions with double-expressor lymphoma or overall survival was not detected. The correlation between immunexpressions of p53 and MYC was observed. The loss of expression of mismatch repair proteins was not observed in any cases. Conclusion: In this study, a relationship between low overall survival and MYC expression is detected. However, our result does not demonstrate that double-expressor lymphoma can be associated with poor outcomes.
Keywords : Diffuse large B cell lymphoma, Double expressor lymphoma, MYC, BCL2, AID, Mismatch repair proteins