The effect of HPV analysis on the ASC/SIL ratio which is one of the quality control criteria for PAP smears

Authors : Ipek ERBARUT SEVEN
Pages : 72-74
Doi:10.5472/marumj.869541
View : 55 | Download : 9
Publication Date : 2021-01-29
Article Type : Research Paper
Abstract :Objective: The high number of smear tests has a workload on pathologists/cytopathologists, which raises the concern for the quality of diagnoses. The application of high-risk human papillomavirus insert ignore into journalissuearticles values(hr-HPV); analyses with the PAP smear has begun to contribute to the clinical practice. In this study, we aimed to show the effect of hr-HPV analysis on the results of PAP smear via atypical squamous cell/squamous intraepithelial lesion insert ignore into journalissuearticles values(ASC/SIL); ratio on the quality standards. Material and Methods: A total of 12799 cervical cytology reports, between 2014-2016, from the Pathology Department of Marmara University Hospital, were included. Between November 2014 and May 2016, hr-HPV analysis was performed on a total of 4307 cases with Hologic Aptima HPV™, USA. Smear diagnoses before and after the start of the HPV test application were recorded. Results: The cytology diagnoses, during when hr-HPV screening was not performed, were: negative for intraepithelial lesion or malignancy insert ignore into journalissuearticles values(NILM); 99.4%, atypical squamous cells of undetermined significance insert ignore into journalissuearticles values(ASCUS); 0.6%, low-grade squamous intraepithelial lesion insert ignore into journalissuearticles values(LSIL); 0.2%, ASC-H 0.04%, and high-grade squamous intraepithelial lesion insert ignore into journalissuearticles values(HSIL); 0.13%. The cytology diagnoses that were evaluated with HPV test were as follows: NILM 93.67%, ASCUS 2.31%, LSIL 2.82%, ASC-H 0.3%, and HSIL 0.91%. ASC/SIL ratio has been dropped from 1.9 to 0.7 after the initiation of hr-HPV use. Conclusion: During the period without hr-HPV analysis, the ASC/SIL ratio was 1.9. Later with the initiation of hr-HPV screening this ratio decreased to 0.7. This shows that knowing HPV test results affects and improves the quality of the laboratory diagnoses.
Keywords : ASC SIL ratio, quality, PAP smear, HPV analysis

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