Are histomorphologic changes in the fimbrial ends more to blame for primary epithelial ovarian carcinomas than initially thought?

Authors : Gokce ASKAN, Ipek ERBARUT SEVEN, Naziye OZKAN, Funda EREN

Pages : 23-30

Doi:10.5472/marumj.1056169

View : 23 | Download : 9

Publication Date : 2022-01-31

Article Type : Research Paper

Abstract :Objective: To investigate the relationship between primary epithelial ovarian tumors and histomorphologic changes in the fimbrial ends insert ignore into journalissuearticles values(FEs); of the fallopian tubes. Materials and Methods: Twenty-eight serous carcinomas insert ignore into journalissuearticles values(SCs); and 12 non-serous carcinomas insert ignore into journalissuearticles values(NSC); were studied. Ovarian and concomitant invasive tumors in FEs were labeled with PAX8, WT-1 and Calretinin. Results: Eighty-six percent of SCs were high grade insert ignore into journalissuearticles values(HG);, 14% of were low grade insert ignore into journalissuearticles values(LG);. 71% of SCs insert ignore into journalissuearticles values(85% HG, 15% LG); had concomitant invasive tumors in FEs. Serous tubal intraepithelial carcinoma insert ignore into journalissuearticles values(STIC); was seen in 29% insert ignore into journalissuearticles values(75% HG, 25% LG);, all had concomitant invasive tumors in FEs. The presence of tumors in FEs was statistically significant in SCs insert ignore into journalissuearticles values(p=0.03);. 33% of NSCs had concomitantly invasive tumors in FEs. 67% of endometrioid tumors, 33% of clear cell carcinomas had endometriosis. 50% of mucinous tumors, 67% of endometrioid tumors, 50% of benign Brenner tumors had Walthard nest. Except for mucinous carcinomas, ovarian and concomitant invasive tumors in FEs displayed tubal phenotype insert ignore into journalissuearticles values(Calretinin-/PAX8+);. Conclusion: The results of our study suggest that, invasive tumors and STIC in FEs are not only limited to HGSCs, but can also be seen in LGs. FEs could also be a site of origin for NSCs, however, future studies with more cases are needed.
Keywords : Primary epithelial ovarian tumors, fallopian tubes, fimbrial ends, histomorphologic changes, early detection