The effect of performance score, prognostic nutritional index, serum neutrophil-to-lymphocyte ratio, and thrombocyte-to-lymphocyte ratio on prognosis in non-small cell lung cancer

Authors : Tibel TUNA, Yasemin KEMAL, Yusuf Taha GULLU, Nurhan KOKSAL, Selen ALA

Pages : 94-99

Doi:10.5472/marumj.1065820

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Publication Date : 2022-01-31

Article Type : Research Paper

Abstract :Objective: Systemic inflammatory markers and nutritional status of the patients can be helpful both in identifying high-risk cancer patients and in showing the prognosis of the disease. In this study we aimed to determine the effects of nutritional status and systemic inflammatory markers on prognosis in non-small cell lung cancer. Patients and Methods: Patients diagnosed with lung cancer between 2015 and 2019 were analyzed retrospectively. The prognostic nutritional index insert ignore into journalissuearticles values(PNI);, platelet-to-lymphocyte ratio insert ignore into journalissuearticles values(PLR); and neutrophil-to-lymphocyte ratioinsert ignore into journalissuearticles values(NLR); were calculated and Eastern Cooperative Oncology Group performance status insert ignore into journalissuearticles values(ECOG PS);, and the dates of death or last follow-up were recorded. Cox regression analysis and Kaplan-Meier curves were used to analyze the effects of parameters on survival. Results: In the study, a total of 219 patients were analyzed. 85.4% of the patients had died. At the third step Cox regression model, ECOG 3-4 insert ignore into journalissuearticles values(HR:2.18);, PLR insert ignore into journalissuearticles values(HR:1.20); and PNI insert ignore into journalissuearticles values(HR:1.12); predicted the survival times. Patients with PNI>45 had a higher median survival insert ignore into journalissuearticles values(495 days); than patients with PNI<45 insert ignore into journalissuearticles values(314 days);. Conclusion: In order to determine the prognosis of the patients at the time of diagnosis, it is recommended to use PNI and PLR values, which can be obtained through repeated tests and evaluated at low cost, together with performance scores.
Keywords : Lung cancer, Inflammation, Nutritional status