Comparison of the intensity of peripheral inflammation between major depressive disorder and bipolar depression by means of neutrophil-lymphocyte and plateletlymphocyte ratios: The possible role of clinical severity and psychotic features

Authors : Necati SERKUT BULUT, Nese YORGUNER

Pages : 100-106

Doi:10.5472/marumj.1065834

View : 14 | Download : 10

Publication Date : 2022-01-31

Article Type : Research Paper

Abstract :Objective: The present study aimed to compare the intensity of inflammation between major depressive disorder insert ignore into journalissuearticles values(MDD); and bipolar disorder-depressive episode insert ignore into journalissuearticles values(BD-D); by using neutrophil to lymphocyte insert ignore into journalissuearticles values(NLR); and platelet to lymphocyte ratios insert ignore into journalissuearticles values(PLR); as nonspecific markers for peripheral immune response, and to investigate whether and how these parameters correlate with the clinical characteristics of the depressive episodes within and between the diagnoses. Patients and Methods: The medical records of 209 psychiatric inpatients insert ignore into journalissuearticles values(126 diagnosed with MDD, 83 with BD-D); and 150 healthy controls insert ignore into journalissuearticles values(HC); were retrospectively screened to obtain NLR and PLR values. Results: Both MDD and BD-D presented with significantly elevated NLR and PLR compared to HC, with the increase being associated with the severity of depression but not with the presence of psychotic features. The severity of inflammation was found to be of a comparable magnitude between the two conditions, or at least indistinguishable by means of the NLR and PLR. Conclusion: Our results suggest that both MDD and BD-D involve a presumably complex inflammatory process resulting in an observable, albeit nonspecific alteration in the distribution of peripheric blood cells. Moreover, the magnitude of the observed immune response appears to relate to the severity of the depressive episode for both conditions.
Keywords : Major depressive disorder, Bipolar disorder, Inflammation, Immune dysregulation, Neutrophil lymphocyte ratio, Plateletlymphocyte ratio