The oncological outcomes of postoperative radiotherapy in patients with stage II and III upper rectal cancer

Authors : Ilknur ALSAN CETIN, Sıtkı Utku AKAY

Pages : 225-229

Doi:10.5472/marumj.1121383

View : 12 | Download : 11

Publication Date : 2022-05-30

Article Type : Research Paper

Abstract :Objective: We assessed the oncological outcomes of postoperative radiotherapy and chemotherapy in patients with stage II or III upper rectal cancer who had undergone curative surgery. Patients and Methods: We retrospectively investigated 133 patients who underwent primary curative resection of stage II or III upper rectal cancer. The median age was 62 years insert ignore into journalissuearticles values(range 30–82 years);. Among these patients, 48% were stage II and 52% stage III. All received postoperative radiotherapy, and most received adjuvant 5-fluorouracil-based chemotherapy for 6 months after radiotherapy ceased. Survival curves were plotted using the Kaplan–Meier method, and survival was compared using the log-rank test. Results: The median follow-up was 71.4 months. The 5-year local recurrence-free survival, cancer specific survival, and overall survival insert ignore into journalissuearticles values(OS); rates were 91.6%, 80.6%, and 75.4%, respectively. Nodal stage 2 insert ignore into journalissuearticles values(p = 0.02, p = 0.05); was a significant predictor of poor local recurrence-free survival and cancer specific survival rates. In the multivariate analysis, older age insert ignore into journalissuearticles values(p = 0.01); and a higher N stage insert ignore into journalissuearticles values(p = 0.01); were independent risk factors for poor OS. Conclusion: The nodal state was predictive of all endpoints in patients with upper rectal stage II or III cancer.
Keywords : Upper rectal cancer, Postoperative radiotherapy, Outcomes