Systemic immune-inflammation index and other inflammatory parameters in patients receiving biological or targeted synthetic DMARDs for inflammatory rheumatic disease

Authors : Halise Hande GEZER, Ozlem PEHLIVAN

Pages : 316-322

Doi:10.5472/marumj.1186732

View : 9 | Download : 8

Publication Date : 2022-10-31

Article Type : Research Paper

Abstract :Objective: To investigate the short – and long-term dynamics in inflammation markers [systemic immune-inflammation index insert ignore into journalissuearticles values(SII);, neutrophil/lymphocyte ratio insert ignore into journalissuearticles values(NLR);, platelet/lymphocyte ratio insert ignore into journalissuearticles values(PLR);, and lymphocyte/ monocyte ratio insert ignore into journalissuearticles values(LMR);] before and after biological disease-modifying antirheumatic drugs insert ignore into journalissuearticles values(bDMARD); or targeted synthetic DMARD insert ignore into journalissuearticles values(tsDMARD); treatment. Patients and Methods: Two hundred twenty-six patients insert ignore into journalissuearticles values(115 women, 47±13.8 years); were included. Age, gender, disease duration, and treatments were recorded retrospectively. Complete blood counts including neutrophil, lymphocyte, platelet, monocyte and acute phase reactants were noted at the visit before the biological treatment, at the 3rd month, 6th month, and the last visit on medication. SII, NLR, PLR and LMR were calculated, and their dynamics over time were compared. Results: Significant changes were observed over time in all parameters reflecting inflammation insert ignore into journalissuearticles values(SII, NLR, PLR, LMR, ESR, and CRP); insert ignore into journalissuearticles values(p<0.05);. In the correlation analysis of changes at baseline and six months, significant correlations with ΔESR were observed with ΔCRP, ΔPLR, ΔSII and ΔNLR insert ignore into journalissuearticles values(p<0.05);, but no correlation with LMR was detected. Also, significant correlations with ΔCRP were noted with ΔNLR, ΔSII, ΔPLR, and ΔLMR insert ignore into journalissuearticles values(p<0.05);. Conclusion: Significant and favourable changes were observed in all inflammatory parameters after treatment, and this variation remained stable as long as the drug was continued.
Keywords : Inflammation, Systemic immune inflammation index, Biological treatment, Inflammation, Systemic immune inflammation index, Biological treatment