Thyroid diseases in patients with active endogenous Cushing’s syndrome

Authors : Tayfur TOPTAS, Kubra Bercem KAHRAMAN, Zilan TOPCU, Hayri BOSTAN, Pinar KADIOGLU

Pages : 257-262

Doi:10.5472/marumj.1186788

View : 14 | Download : 1

Publication Date : 2022-10-31

Article Type : Research Paper

Abstract :Objective: Data about the impact of Cushing’s syndrome insert ignore into journalissuearticles values(CS); on thyroid is scarce. We aimed to identify the prevalence of thyroid diseases in patients with CS. Patients and Methods: Nineteen patients with CS and 40 healthy participants were included in the study. All patients were tested for free tri-iodothyronine insert ignore into journalissuearticles values(fT3);, free thyroxine insert ignore into journalissuearticles values(fT4);, thyroid-stimulating hormone insert ignore into journalissuearticles values(TSH);, anti-thyroglobulin insert ignore into journalissuearticles values(anti-Tg);, and antithyroid peroxidase insert ignore into journalissuearticles values(anti-TPO); levels, and thyroid ultrasonography insert ignore into journalissuearticles values(US);. Results: Overt hypothyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism was evident in 5.3%, 5.3%, and 21.1% of patients with CS; and 2.5%, 7.5%, and 15% of healthy subjects, respectively. fT3 and fT4 levels were lower in patients with CS. None of the patients with CS and 27.5% of the control group had autoimmune thyroid disease insert ignore into journalissuearticles values(AITD);, which was demonstrated by both US findings and anti-TPO positivity insert ignore into journalissuearticles values(P=0.01);. Frequency of thyroid nodule was 52.6% and 52.5% in patients with CS and controls, respectively insert ignore into journalissuearticles values(P=0.99);. Conclusion: The prevalence of thyroid dysfunction, nodular thyroid disease, and goiter is comparable to healthy population. However, AITD is less prevalent among patients with CS. Although, hypercortisolism has an impact on hypothalamic-hypophyseal-thyroid axis, its clinical implication does not seem to be significant.
Keywords : Cushings syndrome, Thyroid diseases, Thyroid nodule, Hypercortisolism, Autoimmune thyroid disease