Partial healing effects of St. John’s wort oil on the rat excisional wound model

Authors : Ayse Nilhan AKSU, Tayfun BILGIC, Cavit Kerem KAYHAN, Zumrut Mine ISIK SAGLAM, Nazli CAF

Pages : 281-287

Doi:10.5472/marumj.1186858

View : 16 | Download : 8

Publication Date : 2022-10-31

Article Type : Research Paper

Abstract :Objective: St. John’s wort insert ignore into journalissuearticles values(SJW); oil insert ignore into journalissuearticles values(Hypericum perforatum); has been used for its immunomodulatory and anti-inflammatory effects. Several studies have shown the efficacy of SJW on wound healing. The aim of this study is to assess the effectiveness of SJW using a combination of biochemical, histopathological and laser Doppler evaluations. Materials and Methods: Sixteen young Wistar albino rats were used as case and control groups insert ignore into journalissuearticles values(having 8 in each group);. After anesthesia protocol, 6 mm punch biopsy was taken from six separate sites on the rats’ dorsal skin. Three wounds were stitched insert ignore into journalissuearticles values(closed wounds);; three wounds were left as they were insert ignore into journalissuearticles values(open wounds);. SJW oil was administered topically to case group once a day for 14 days. Controls did not receive any treatment. Results: There was no statistical difference in blood perfusion between the groups. No statistical difference was present between the groups in GPx insert ignore into journalissuearticles values(glutathione peroxidase);values. Rat MDA insert ignore into journalissuearticles values(malonyldialdehyde); values were higher in the case group compared to the control group. SJW oil was found to be beneficial and effective within some histological parameters. Conclusion: SJW may be an effective salve within some parameters. Nevertheless, this judgment is uncertain due to the low sample size. We encourage further studies on this promising natural medicine.
Keywords : Antiinflammatory, fibroblast, glutathione peroxidase, St Johns wort, wound