Comparison of respiratory morbidity in late preterm infants and intrauterine growth retarded infants at school-age

Authors : Mahmut Caner US, Ulfet VATANSEVER, Ridvan DURAN, Betul ACUNAS

Pages : 335-342

Doi:10.5472/marumj.1195309

View : 10 | Download : 8

Publication Date : 2022-10-31

Article Type : Research Paper

Abstract :Objective: We aimed to determine respiratory morbidity of late preterm infants versus infants with intrauterine growth retardation insert ignore into journalissuearticles values(IUGR); at school-age. Patients and Methods: Late preterm appropriate for gestational age insert ignore into journalissuearticles values(AGA); infants insert ignore into journalissuearticles values(34-36, 6/7 weeks); insert ignore into journalissuearticles values(Group 1);, IUGR infants insert ignore into journalissuearticles values(Group 2);, extremely preterm AGA insert ignore into journalissuearticles values(Group 3); and term AGA infants insert ignore into journalissuearticles values(Group 4); born between 2004 and 2008 were included in this casecontrol study and assessed for respiratory morbidity at school-age. We evaluated the impact of late preterm compared with IUGR and term gestation on respiratory morbidity by using validated American Thoracic Society – Division of Lung Diseases insert ignore into journalissuearticles values(ATS-DLD-78-C); and the International Study of Asthma and Allergies in Childhood insert ignore into journalissuearticles values(ISAAC); questionnaires. Questionnaires on wheezing, infectious respiratory morbidity, and physician-diagnosed asthma panels were constituted and groups were compared. Results: A total of 160 patients were enrolled in the study and 97 insert ignore into journalissuearticles values(60.6%); of them were boys. Respiratory morbidities at schoolage were found to be significantly higher in both late preterm and IUGR groups when compared to term controls. Each weekly increase in gestational age reduced the risk for wheezing episodes insert ignore into journalissuearticles values(OR perGW:0.82,95%CI:0.71-0.97, p:0.02);. Regarding infectious respiratory morbidities, there was a significant increase when the number of people living at home increased insert ignore into journalissuearticles values(OR perperson:1.79,95%CI:1.12-2.87, p:0.01);, and a decrease in female gender insert ignore into journalissuearticles values(OR:0.41,95%CI:0.17-0.99, p:0.04); and in the week of gestation insert ignore into journalissuearticles values(OR perGW:0.84,95%CI:0.71-1.00, p:0.04);. Atopic dermatitis insert ignore into journalissuearticles values(OR:5.26,95%CI:1.57-17.69, p<0.01); and maternal asthma insert ignore into journalissuearticles values(OR:5.38,95%CI:1.17-24.60, p:0.03); history were found to be risk factors for asthma. Conclusion: Being IUGR may be an important risk factor for respiratory morbidity at school-age. Further studies are needed on this subject.
Keywords : Premature Birth, Late preterm, Fetal Growth Retardation, Asthma, School age