Association of the changes in pulmonary artery diameters with clinical outcomes in hospitalized patients with COVID-19 infection: A crosssectional study

Authors : Aybuke SELCUK, Can ILGIN, Sait KARAKURT

Pages : 355-361

Doi:10.5472/marumj.1195539

View : 10 | Download : 12

Publication Date : 2022-10-31

Article Type : Research Paper

Abstract :Objective: Enlarged pulmonary artery diameter insert ignore into journalissuearticles values(PAD); can be associated with mortality risk in coronavirus disease 2019 insert ignore into journalissuearticles values(COVID-19); patients. Our aim is to find the factors that cause changes in PAD and the relationship between radiological findings and clinical outcomes in COVID-19 patients. Patients and Methods: In this descriptive, retrospective, and single centered study, among the hospitalized 3264 patients, 209 patients with previous chest computed tomography insert ignore into journalissuearticles values(CT); were included. Findings of current chest CTs of patients obtained during COVID-19 were compared with that of previous chest CTs. Pulmonary involvements, World Health Organization insert ignore into journalissuearticles values(WHO); Clinical Progression Scale scores and laboratory variables were recorded. Intensive Care Unit insert ignore into journalissuearticles values(ICU); admission, intubation and mortality were clinical outcomes that were evaluated by using uni – and multivariate analyses. Results: Patients with high D-dimer had significantly increased risk for enlarged PAD and increase in PAD compared to previous chest CT insert ignore into journalissuearticles values(ΔPAD); insert ignore into journalissuearticles values(OR=1.18, p<0.05, OR=1.2 p<0.05);. Both high D-dimer and an increase over 2 mm in PAD insert ignore into journalissuearticles values(ΔPAD 2mm); had significant risks for ICU admission, intubation, and mortality insert ignore into journalissuearticles values(OR= 1.18 p<0.01, OR=1.22 p<0.01, OR=2.62 p<0.05, OR=2.12 p<0.01, OR=2.32 p<0.01, OR=2.09 p<0.001 respectively);. It was found that with enlarged PAD, risk of ICU admission and mortality increased. insert ignore into journalissuearticles values(OR=3.03 p<0.001, OR=2.52 p<0.01);. Combined with age and lymphocyte counts, PAD predicted mortality with a 50% sensitivity, 88% specificity insert ignore into journalissuearticles values(AUC=0.83, p<0.001);. Conclusion: PPatients with an increase over 2 mm insert ignore into journalissuearticles values(ΔPAD 2mm); in PAD had significantly increased clinical severity, ICU admission, intubation, and mortality. High levels of D-dimer and CRP in patients suggest that increased inflammation and thrombosis may be effective in pathogenesis.
Keywords : Pulmonary artery diameter, COVID 19, Thromboembolism, CoRad, WHO score