Endogenous maternal serum preimplantation factor levels in earlyonset preeclamptic pregnancies

Authors : Muhammet Atay OZTEN, Ece KARACA

Pages : 203-209

Doi:10.5472/marumj.1229910

View : 41 | Download : 120

Publication Date : 2023-05-31

Article Type : Research Paper

Abstract :Objective: Preimplantation-factor insert ignore into journalissuearticles values(PIF); is a new peptide with many potential functions. We aimed to compare the maternal serum PIF levels among early-onset preeclamptic patients with the healthy controls at the same gestational age. Patients and Methods: Thirty-nine early-onset preeclamptic insert ignore into journalissuearticles values(< 34 gestational weeks); patients and 45 healthy expecting women have been added to our study. Patients with or suspicion of any chronical maternal disease, gestational diabetes, twin pregnancies, fetal or placental anomalies or any other obstetric complications have been excluded. Competitive enzyme-linked immunosorbent assay insert ignore into journalissuearticles values(ELISA); insert ignore into journalissuearticles values(Elabscience Biotechnology Co., Texas, USA); has been used to analyze the PIF levels in the collected samples. Gestational age, maternal age, gravida, parity, fetal growth, body mass index insert ignore into journalissuearticles values(BMI);, maternal weight and height, plasma PIF levels have been collected/measured and analyzed in both groups. Results: The primary outcome of our study –the Preimplantation Factor- was significantly higher in study group than the healthy controls insert ignore into journalissuearticles values(100.36 ± 41.92 vs. 83.14 ± 51.27 p=0.016);. Conclusions: We have found the PF levels statistically higher in the study group. PIF levels might have a role in the progression and pathogenesis of the preeclamptic patients. Further studies with larger groups have to be planned and performed to resolve the real relation between PIF and preeclampsia.
Keywords : Preimplantation Factor, Preeclampsia, Maternal Serum