How does an additional insulin dose for a high-fat, high-protein breakfast affect glysemic response in adolescents with type 1 diabetes?

Authors : Aylin BAYINDIR GUMUS, Alev KESER, Zeynep SIKLAR, Merih BERBEROGLU

Pages : 242-248

Doi:10.5472/marumj.1302393

View : 49 | Download : 223

Publication Date : 2023-05-31

Article Type : Research Paper

Abstract :Objective: In this study, it was aimed to evaluate the effects of an additional insulin dose for high-fat and high-protein meal on blood glucose levels in adolescents with type 1 diabetes. Patients and Methods: This study was single-center, crossover, and randomized. Seven adolescents with type 1 diabetes between the ages of 14 and 17 were given breakfast containing high-fat insert ignore into journalissuearticles values(45.9% energy); and high-protein insert ignore into journalissuearticles values(21.9% energy); for two consecutive days, and two different insulin doses were administered. According to the first application dose of carbohydrate/insulin ratio, the second application was given this dose of additional insulin up to 30% in postprandial 180th minute. Blood glucose was monitored for 360 minutes at 30-minute intervals using a continuous glucose monitoring system insert ignore into journalissuearticles values(CGMS);. Results: The average time spent in the target range insert ignore into journalissuearticles values(TIR); of participants was 30.6±11.83%, and time spent in hyperglycemia and hypoglycemia insert ignore into journalissuearticles values(time above range insert ignore into journalissuearticles values(TAR); and time below range insert ignore into journalissuearticles values(TBR);); were 67.0±14.31% and 2.4±4.89%, respectively. There was no statistically significant difference between the early insert ignore into journalissuearticles values(0-120th min);, late insert ignore into journalissuearticles values(120-360th min);, and total insert ignore into journalissuearticles values(0-360th min); glycemic responses of the applications insert ignore into journalissuearticles values(p>0.05);. According to CGMS result, mean blood glucose, glycemic variability, and absolute blood glucose difference median and mean absolute deviation insert ignore into journalissuearticles values(MAD%); were found to be similar after two applications insert ignore into journalissuearticles values(p>0.05);. Conclusion: Insulin dose applications should be individually calculated to prevent delayed-prolonged postprandial hyperglycemia caused by high-fat high – protein intake in adolescents with type 1 diabetes.
Keywords : Type 1 diabetes, Preprandial insulin, Fat and protein counting, Meal pattern, Meal pattern