Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients

Authors : Zeynep MERCANCI, Can ILGIN, Sehnaz OLGUN YILDIZELI, Derya KOCAKAYA, Baran BALCAN, Buket ERTURK SENGEL, Sait KARAKURT, Emel ERYUKSEL

Pages : 175-181

Doi:10.5472/marumj.1302440

View : 35 | Download : 114

Publication Date : 2023-05-31

Article Type : Research Paper

Abstract :Objective: Coagulopathy is thought to play an important role in the development of severe COVID-19. High D-dimer levels have been reported in Chinese cohort studies. However, ethnicity has significant implications for thrombotic risk. Our aim in this study is to determine the effect of D-dimer measurements on disease prognosis and mortality in Turkish patients with COVID-19. Patients and Methods: The study was designed retrospectively. Patients over the age of 18 who were admitted to our hospital were included in the study. Results: The study included 226 patients. According to the World Health Organization staging, 75insert ignore into journalissuearticles values(33.2%); patients, according to the staging of Siddiqi et al., 67 insert ignore into journalissuearticles values(29.7%); patients progressed. In the ROC analysis performed to predict mortality, AUC value for D-dimer was found to be 82.25% insert ignore into journalissuearticles values(95%CI 74.8%-89.71%);. When the cut-off value for D-dimer was accepted as ≥3.25mg/L, specificity was 94.15%, correctly classified rate 88.5%, positive likelihood ratio as insert ignore into journalissuearticles values(LR);:5.69, negative LR:0.71. Conclusion: As a result, similar to the Chinese cohorts, elevated D-dimer measurements increase disease progression and mortality in Turkish patients with COVID-19. D-dimer levels of 3.25 mg/L and above, strongly determine the risk of increased mortality in the Turkish Caucasian ethnic group.
Keywords : COVID 19, D dimer, Mortality, Ethnicity