The effect of serum activated ghrelin hormone on glycemic control in the diabetic patients with excessive body mass index

Authors : Yilmaz FAKI, Semih KALYON

Pages : 171-174

Doi:10.5472/marumj.1307861

View : 40 | Download : 117

Publication Date : 2023-05-31

Article Type : Research Paper

Abstract :Objective: In the literature, plasma ghrelin level was found to be lower in patients with obesity or diabetes in a few studies. However, there is no study comparing ghrelin level in non-diabetic and diabetic patients with overweight or obesity. We have two aims in this study; first to show whether plasma ghrelin levels in type 2 diabetes mellitus patients with excessive body mass index insert ignore into journalissuearticles values(BMI); decrease the level of a cumulative ghrelin which we expect in both diabetes-related and obesity-related conditions, secondly to study whether there is a correlation between ghrelin level and diabetes complications. Patients and Methods: Ethics committee decision and written informed consent from patients were received before the study. 57 BMI≥25 type 2 diabetic patients treated and followed up in the diabetic outpatient clinic and 25 BMI≥25 subjects without diabetes mellitus insert ignore into journalissuearticles values(control group); were included in this case-control study. Pregnant women, patients with malignancy and under 18 years old were excluded. The results were evaluated by the SPSS statistical program. Results: The ghrelin and BMI values of the diabetic patients with excessive BMI and the non-diabetic patients with excessive BMI were not statistically different. No statistical significant correlation between ghrelin and haemoglobin A1c insert ignore into journalissuearticles values(HbA1C);, BMI, retinopathy, neuropathy, albuminuria, and macrovascular complications was found in the type 2 diabetic patients with overweight or obesity. Conclusion: The presence of diabetes in addition to patients with excessive BMI does not cause ghrelin levels to decrease more than expected.
Keywords : Ghrelin, Diabetes Mellitus, Obesity, Overweight