Congenital cytomegalovirus infection cases and follow-up findings in Antalya, Turkey

Authors : Zubeyde ERES SARITAS, Bilal Olcay PEKER, Dilek ÇOLAK, Imran SAGLIK, Rabia Can SARİNOĞLU, Murat TURHAN, Aslı BOSTANCI TOPTAŞ, Derya MUTLU, Gözde ÖNGÜT, Nihal OYGUR, Munire ERMAN

Pages : 290-296

Doi:10.5472/marumj.1367753

View : 28 | Download : 52

Publication Date : 2023-09-29

Article Type : Research Paper

Abstract :Objective: To investigate the presence of cCMV infection and the CMV-DNA virus in the newborns who applied for newborn hearing screening test insert ignore into journalissuearticles values(NHST); and CMV-DNA viruria with physical, mental-motor development and hearing status of cCMV cases in the second year of age. Patients and Methods: CMV-DNA was investigated in 1150 newborns’ oral swabs insert ignore into journalissuearticles values(0-21 days); by polymerase chain reaction kit and urine of patients with positive CMV-DNA in saliva. Transient Evoked Otoacoustic Emission test was performed for NHST. Results: CMV-DNA was posititve in saliva of 38 insert ignore into journalissuearticles values(3.3%); newborns and urine of 10 out of 37 newborns. The prevalence of cCMV was 0.87% insert ignore into journalissuearticles values(95% CI=0.697-1.042);. All newborns passed the NHST. In newborns with cCMV:jaundice in 60% insert ignore into journalissuearticles values(6/10);, low birthweight in 40% insert ignore into journalissuearticles values(4/10);, small for gestational age in 50% insert ignore into journalissuearticles values(5/10); of them. Jaundice was the most significant variable insert ignore into journalissuearticles values(P<0.001, OR:23.411, 95% CI=5.772-94.960); and bilirubin levels were slightly elevated. In the second year of 8 cases, CMV-DNA viruria was detected in all of them and sensorineural hearing loss was detected in one infant. Conclusion: The cCMV infection rate is 0.87% in a population with high maternal seropositivity.When diagnosing cCMV, saliva may give false-positive results and urine should be tested. Bilirubin levels may not be as high as expected in cCMV cases in highly seroimmune populations and sequelaes may occur in the following years.
Keywords : Congenital CMV infection, High seroprevalence population, Urine, Saliva, CMV DNA PCR