Correlation of Platelet to Lymphocyte Ratio with Presence and Severity of Metabolic Syndrome

Authors : Yasemin Kaya, Osman Bektaş, Ahmet Kaya, Zeki Günaydın, Adil Bayramoğlu, Mustafa Çalgın

Pages : 18-24

Doi:10.19127/mbsjohs.32758

View : 26 | Download : 11

Publication Date : 2015-12-30

Article Type : Research Paper

Abstract :Objective: The aim of this study is to evaluate the relation between the components of Metabolic syndrome insert ignore into journalissuearticles values(MS); and the inflammation and the platelet-to-lymphocyte ratio insert ignore into journalissuearticles values(PLR); recognized as a novel marker of pro-thrombotic state. Method: 70 patients with MS criteria were included in the study. 70 healthy people with matching age and gender characteristics were included in the study as the control group. The patients were divided into three groups with regard to the number of MS characteristics: Group 1 insert ignore into journalissuearticles values(the patients with three MS criteria);, group 2 insert ignore into journalissuearticles values(the patients with four MS criteria);, and group 3 insert ignore into journalissuearticles values(the patients with five MS criteria);. PLR was calculated in regard to the complete blood count. Results: The patients with MS had significantly higher PLR level compared to those without MS. However, PLR level were not associated with severity of MS. A moderate positive correlation was revealed between the severity of MS and PLR insert ignore into journalissuearticles values(r=0.419, p<0.001); and a strong positive correlation between the severity of MS and hs-CRP insert ignore into journalissuearticles values(r=0.562, p<0.001);. Also, a positive correlation was detected between hs-CRP and PLR in our patient population insert ignore into journalissuearticles values(r=0.281, p=0.002);. In order to specify the level of PLR to predict MS, ROC curve analysis was performed. The cut-off level for PLR with optimal sensitivity and specificity was calculated as 0,132 insert ignore into journalissuearticles values(Area under curve [AUC] =0.744 [0.655-0.833], p<0.001);. For that level, the sensitivity was 73% and the specificity was 68, 4%. Conclusion: This is the first study which determines the fact that there is a relation between MS criteria, the inflammation and PLR, which is a new marker of the pro-thrombotic state. There is also a positive correlation between PLR and hs-CRP in these patients. PLR may be beneficial in predicting the adverse cardiovascular cases in the patients with MS.
Keywords : Metabolic Syndrome, Platelet lymphocyte ratio, Inflammation