Effects of Autologous Platelet-Rich Plasma on Endometrium Thickness and Pregnancy Rates During Intrauterine Insemination

Authors : Mehmet SİPAHİ

Pages : 63-66

Doi:10.19127/mbsjohs.544429

View : 19 | Download : 8

Publication Date : 2019-08-28

Article Type : Research Paper

Abstract :Objective: Evaluation of the effect of platelet-rich plasma insert ignore into journalissuearticles values(PRP); on the endometrium and pregnancy outcomes in patients undergoing insemination due to unexplained infertility. Methods: 24 patients who were admitted to the clinic due to unexplained infertility, analyzed retrospectively between March 2018 and October 2018. Gonadotropin induction was initiated on day 3 of the cycle for follicular growth. Human chorionic gonadotropin insert ignore into journalissuearticles values(hCG); was applied for ovulation induction at the point that at least 1 follicle that is over 16 mm was detected by transvaginal ultrasound. 17.5 ml of blood from the patient`s venous system was drawn for the preparation of the PRP which includes 4-5 times more platelets than regular blood. PRP was administered to 12 patients insert ignore into journalissuearticles values(Group 1); on the hCG day, while hCG was solely administered to the other group insert ignore into journalissuearticles values(Group 2); and both groups were inseminated 36 hours later. Results: The demographic properties of all patients were determined as follows: mean age; 29.13 years old insert ignore into journalissuearticles values(±3.4);, mean infertility period; 1.96 years insert ignore into journalissuearticles values(±1.08);, mean ovulation induction period; 7.92 days insert ignore into journalissuearticles values(±1.76);, mean antral follicle count; 14.54 insert ignore into journalissuearticles values(±6.56);, mean dominant follicle count; 2.04 insert ignore into journalissuearticles values(±0.75);. Although there was no significant difference between the groups in terms of clinical pregnancy insert ignore into journalissuearticles values(3/12 vs 2/12, p: 0.623);, the change in endometrial thickness was significantly higher in the PRP administered group insert ignore into journalissuearticles values(1.95 mm vs 0.44 mm, p< 0.001);. Conclusion: PRP application before the insemination seems promising for the preparation of the endometrium in patients having an inadequate endometrial thickness or in patients experiencing recurrent implantation failure.
Keywords : intrauterine insemination, endometrial thickness, autologous platelet rich plasma, infertility, pregnancy rate