Indicators of Isotretinoin-Induced Myopathy: Neutrophil/Lymphocyte Ratio, Cobb Angle of Spine

Authors : Densel ARAÇ, Rukiye GÜNER

Pages : 299-304

Doi:10.19127/mbsjohs.776897

View : 23 | Download : 7

Publication Date : 2020-12-31

Article Type : Research Paper

Abstract :Objective: There are many side effects of isotretinoin on the musculoskeletal system, liver, nervous system and dermatological side effects. To investigate usage and side effects of isotretinoin insert ignore into journalissuearticles values(13-cis retinoic acid);, which is popularly recommended by dermatologists for the treatment of acne vulgaris, on young patients admitted to the hospital with severe low back and neck pains. Methods: We evaluated 61 patients who, using isotretinoin for the treatment of acne vulgaris for an average of eight months, experienced cervical and lumbar pain between 2017-2019. The age range of patients was between 16 and 38 years, there were 45 female and 16 male patients. These patients used isotretinoin at a dose of 0.5-0.8 mg/kg/day for the treatment of acne vulgaris for about eight months. The patients were questioned about cervical and lower back pain, joint pain, muscle weakness, myoglobinuria, creatine phospo-kinase insert ignore into journalissuearticles values(CPK);, Visual Analog Scale insert ignore into journalissuearticles values(VAS);, inflammation myopathy, neutrophil/lymphocyte ratio insert ignore into journalissuearticles values(Neu/Lymp ratio);, and Cobb angle of the spine during monthly controls. Results: The VAS and Neu/Lymp ratio, cervical and lumbar Cobb angles of the patients were statistically analyzed and the relationship between them was shown. Conclusion: The Neu/Lymp ratio and Cobb angle of the cervical and lumbar spine should be considered as an alternative or additional parameter to diagnose drug-induced myopathy.
Keywords : Neu Lymp ratio, Myopathy, cob angle, inflamation, pain