Relationship Between Kawasaki Syndrome and Viral Infection

Authors : Ceren YAPAR GÜMÜŞ, Nurdan EROL, Nihan UYGUR KÜLCÜ

Pages : 98-105

Doi:10.19127/mbsjohs.1038969

View : 23 | Download : 11

Publication Date : 2022-02-25

Article Type : Research Paper

Abstract :Objective: This study aimed to investigate the relationship between Kawasaki syndrome and viral infections. Methods: The data of the Kawasaki syndrome cases diagnosed between January 2017 to December 2019 were reviewed from hospital records retrospectively. Results: Among eighteen cases ten were boys, and eight were girls. Their average age at diagnosis was 38.28 ± 28.38 insert ignore into journalissuearticles values(3-113 months);. Seven cases were in winter, eight in spring and autumn, and three in summer diagnosed. The mean length of stay in the hospital was 7.41±3.34 insert ignore into journalissuearticles values(3-17 days);. All patients presented with fever, and the mean duration of fever was 6.94 ± 1.63 days. Six cases were classified as typical KS insert ignore into journalissuearticles values(33.3%);, and twelve as atypical KS insert ignore into journalissuearticles values(66.7%);. Laboratory examinations revealed a leukocyte count of 16507 ± 61817 /mm³, C-reactive protein 8.59 ±5.87 mg/dl, erythrocyte sedimentation rate insert ignore into journalissuearticles values(ESR); median value 58 mm/hour insert ignore into journalissuearticles values(18-102);. Fourteen patients had cardiac involvement insert ignore into journalissuearticles values(pericardial effusion, mitral insufficiency);, and six had small coronary artery involvement. Both cardiac and coronary artery involvement rates were higher in the atypical KS. In only six cases insert ignore into journalissuearticles values(33.3%); were the pathogens detected. The detected infectious agents were: Parainfluenza type 4, Parainfluenza type 3, Respiratory syncytial virus, Group A streptococcus, Epstein-Barr virus, Ochrobactrumanthropi, Rubella, Cytomegalovirus. Conclusion: Detection of infectious agents in only one-third of the cases and the presence of different factors suggest that the Kawasaki syndrome is not related to a specific pathogenic agent. Coronary involvement was not found to be associated with pathogenic agents. However, atypical KS needs more attention for cardiac involvement.
Keywords : Kawasaki syndrome, vasculitis, viral infections