One Year Analysis of Hematological and Inflammatory Parameters to Predict the Severity of COVID-19 Infection in Pregnant Women

Authors : Seda KESKİN, Deha Denizhan KESKİN

Pages : 146-157

Doi:10.19127/mbsjohs.1064479

View : 20 | Download : 9

Publication Date : 2022-02-25

Article Type : Research Paper

Abstract :Objective: The study aims to demonstrate the usability of admission hematological parameters in the prognosis of COVID-19 infection in pregnant population and to introduce the cut-offs values of these parameters for pregnant women. Methods: The cohort of this retrospective study consisted of 71 COVID-19 PCR positive pregnant women who were hospitalized in Ordu University Medical Faculty Training and Research Hospital between 1 May 2020 and 1 May 2021. The pregnant women were divided into two groups based on the severity of the disease. Results: White blood cell count, neutrophil count and C-reactive protein insert ignore into journalissuearticles values(CRP); levels was significantly higher insert ignore into journalissuearticles values(p=0.000, p=0.000);, whereas red blood cell count and lymphocyte count were significantly lower insert ignore into journalissuearticles values(p=0.002, p=0.002); in severe group. High NLR insert ignore into journalissuearticles values(neutrophil-to-lymphocyte ratio); insert ignore into journalissuearticles values(p=0.000);, dNLR insert ignore into journalissuearticles values(derived neutrophil-to-lymphocyte ratio); insert ignore into journalissuearticles values(p=0.000);, MLR insert ignore into journalissuearticles values(monocyte-to-lymphocyte ratio); insert ignore into journalissuearticles values(p=0.004);, PLR insert ignore into journalissuearticles values(platelet-to-lymphocyte ratio); insert ignore into journalissuearticles values(p=0.008);, NPR insert ignore into journalissuearticles values(neutrophil-to-platelet ratio); insert ignore into journalissuearticles values(p=0.005);, NLRNPR insert ignore into journalissuearticles values(neutrophil-to-lymphocyte ratio/neutrophil-to-platelet ratio); insert ignore into journalissuearticles values(p=0.008); and SII insert ignore into journalissuearticles values(Systemic immune inflammation index); insert ignore into journalissuearticles values(p=0.000); were found in severe group. Conclusion: This paper revealed that severe COVID-19 disease in pregnant women is mainly associated with hematological parameters. Among these parameters NLR, dNLR and SII have largest AUC in ROC, with cutoff values 5.3, 3.52 and 994.8 respectively. Further investigations regarding the use of hematologic tests as prognostic factor of COVID-19 disease severity in pregnant women are needed to assess the risk of serious disease, to predict the prognosis of COVID-19 and to reduce perinatal and maternal morbidity/mortality.
Keywords : COVID 19, complete blood count, c reactive protein, hematological parameters, pregnancy