Effects of Uric Acid on Disease Severity and Mortality in Hospitalized Covid-19 Patients

Authors : Ercan TÜRKMEN, Ahmet KARATAŞ, Yusuf Taha GULLU

Pages : 422-431

Doi:10.19127/mbsjohs.1126040

View : 23 | Download : 12

Publication Date : 2022-08-31

Article Type : Research Paper

Abstract :Objective: High and low uric acid insert ignore into journalissuearticles values(UA); levels in the general population are associated with mortality. Information on the association of UA levels with clinical outcomes in COVID-19 patients is contradictory. We investigated the relationship between UA levels and clinical endpoints in COVID-19 patients. Methods: Laboratory and clinical parameters, including UA at the admission of hospitalized COVID-19 patients, were recorded retrospectively. Binary logistic regression analysis determined risk factors for mortality and the intensive care unit insert ignore into journalissuearticles values(ICU); needs. Results: This study included 708 patients insert ignore into journalissuearticles values(57.1% men);, and the median age was 63 insert ignore into journalissuearticles values(18-98); years. Two hundred and three insert ignore into journalissuearticles values(28.7%); patients needed ICU, and 107 insert ignore into journalissuearticles values(15.7%); died. Uric acid levels were significantly higher in the deceased insert ignore into journalissuearticles values(6.5 vs. 4.9; p<0.001);. Uric acid levels were similar in patients who needed ICU and those who did not insert ignore into journalissuearticles values(5 vs. 5.1; p=0.348);. High UA insert ignore into journalissuearticles values(>median value 5.1 mg/dL); group have higher mortality rate insert ignore into journalissuearticles values(22.4% vs. 9.5%; p<0.001);. In multivariate analyses, a high UA level was a risk factor for mortality [OR 1.93 insert ignore into journalissuearticles values(1.08 – 3.44);; p=0.026]. In addition, age [OR 1.03 insert ignore into journalissuearticles values(1.01 – 1.05);; p=0.004], albumin [OR 0.30 insert ignore into journalissuearticles values(0.17 - 0.52);; P<0.001], neutrophil-to-lymphocyte ratio [OR 1.04 insert ignore into journalissuearticles values(1.01 – 1.06);; p=0.003] and procalcitonin [OR 1.06 insert ignore into journalissuearticles values(1.0 – 1.11);; p=0.048] was associated with mortality. A high UA level was not a risk factor for ICU need insert ignore into journalissuearticles values(p=0.780);. Conclusion: High serum UA level affects mortality in COVID-19 patients. Risk assessment for the prognosis of patients can be made according to the UA levels at admission.
Keywords : COVID 19, intensive care, mortality, uric acid