Association of Vitamin D, IL-6, TNF-α, CRP and Periodontal Health Status in the Eastern Black Sea Region

Authors : Hatice YEMENOĞLU, Meltem ZİHNİ KORKMAZ, Medeni ARPA

Pages : 498-510

Doi:10.19127/mbsjohs.1231689

View : 39 | Download : 38

Publication Date : 2023-08-31

Article Type : Research Paper

Abstract :Objective: It is well established that vitamin D deficiency may increase risk of periodontitis, and that supplementation with vitamin D can contribute to maintain periodontal health. Since the Eastern Black Sea Region receives little sunlight due to its location, individuals living in this region don’t produce enough vitamin D and these individuals generally have vitamin D deficiency. The goal of this study was to analyze that association of vitamin D and periodontal health status in a study population of the Eastern Black Sea Region. Methods: In this study, which was planned as a case control study, it was planned to reach a total of 72 samples, with at least 24 samples in each group in the sample calculation. As a result of data collection, 29 individuals with periodontitis, 28 individuals with gingivitis and 25 periodontally healthy individuals, a total of 82 individuals were included in the study. Cytokines in inflamed periodontal tissues have a marked effect on host modulation and onset and progression of periodontal disease. Venous blood samples were collected from the individuals. Periodontal clinical parameters were measured. Serum levels of 1.25insert ignore into journalissuearticles values(OH);2D3, 25insert ignore into journalissuearticles values(OH);D, C-reactive protein insert ignore into journalissuearticles values(CRP);, tumor necrosis factor α insert ignore into journalissuearticles values(TNF-α); and interleukin 6 insert ignore into journalissuearticles values(IL-6); were assessed. Results: Periodontally healthy group had statistically significantly lower periodontal clinical parameter values compared to gingivitis and periodontitis group insert ignore into journalissuearticles values(p<0.05);. The serum 1.25insert ignore into journalissuearticles values(OH);2D3 level was lower in the periodontitis group compared to the periodontally healthy group and gingivitis group insert ignore into journalissuearticles values(p<0.05);. But there was no statistically significant difference in the periodontitis 10.20 insert ignore into journalissuearticles values(3.70-29.50); ng/mL, gingivitis 11.35 insert ignore into journalissuearticles values(5.60-29.50); ng/mL and periodontally healthy groups 9.10 insert ignore into journalissuearticles values(2.90-55.40); ng/mL in terms of serum 25insert ignore into journalissuearticles values(OH);D levels insert ignore into journalissuearticles values(p>0.05);. Conclusion: The outcomes of this study support the idea that lower serum 1.25insert ignore into journalissuearticles values(OH);2D3 level has a negative effect on periodontal health status. Our data suggest that vitamin D supplementation to people living in the Eastern Black Sea Region would be beneficial in reducing the risk of developing periodontal disease. Further studies are needed on this subject.
Keywords : Cytokine, gingivitis, pathogenesis of periodontal disease, periodontitis, 1 25 hydroxyvitamin D