Effects of lithium chloride and methylprednisolone on experimental spinal cord injury

Authors : Mehmet Ali Ekici, Zuhtu Ozbek, Halide Edip Temel Incedal, Omer Colak, Ali Arslantas, Canan Baydemir

Pages : 165-169

Doi:10.18621/eurj.2016.5000131941

View : 21 | Download : 9

Publication Date : 2016-11-04

Article Type : Research Paper

Abstract :Objective. Antioxidant effects of lithium chloride insert ignore into journalissuearticles values(LiCl); and methylprednisolone were investigated in an experimental spinal cord injury. Methods. Spinal cord injury was performed by cerebral vascular clip with a closing force of 40 g; the duration of epidural compression was 30 seconds after T9-11 total laminectomy in the rat spine. The study was conducted in 4 groups. Group 1: sham insert ignore into journalissuearticles values(n=8);, group 2: 0.9% saline insert ignore into journalissuearticles values(n=8);, group 3: LiCl insert ignore into journalissuearticles values(n=8);, group 4: methylprednisolone insert ignore into journalissuearticles values(n=8);. Ketamine insert ignore into journalissuearticles values(60 mg/kg); and 2% xylazine insert ignore into journalissuearticles values(5 mg/kg); were used intraperitoneally as anesthesia protocol for the groups. The rats were sacrificed 24 hours after the injury and blood samples were taken. Total oxidant status insert ignore into journalissuearticles values(TOS);, total antioxidant status insert ignore into journalissuearticles values(TAS);, malondialdehyde insert ignore into journalissuearticles values(MDA); and tumor necrosis factor-α insert ignore into journalissuearticles values(TNF-α); level were analyzed. Results. Median insert ignore into journalissuearticles values(q1-q3); levels of TAS, TOS, MDA and TNF-α were statistically analyzed for the study groups. The TAS values of LiCl yielded statistically significant differences compared with group 1, 2 and 4 insert ignore into journalissuearticles values( p <0.05);. The MDA values of LiCl and methylprednisolone groups were found to significantly differ between the sham and saline groups insert ignore into journalissuearticles values( p <0.05);. There were no statistical differences between the study groups for the TNF-α and TOS values insert ignore into journalissuearticles values( p >0.05);. Conclusion. LiCl seems to be an effective drug for experimental spinal cord injuries.   
Keywords : Spinal cord injury, experimental, treatment, lithium chloride, methylprednisolone