Relation of neutrophil/lymphocyte ratio to resistant hypertension

Authors : Necati DAGLİ, Orhan DOGDU, Omer SENARSLAN, Hasan YUCEL, Hakki KAYA, Mahmut AKPEK, Semih ERİTEN

Pages : 211-218

Doi:10.18621/eurj.2016.5000185856

View : 19 | Download : 10

Publication Date : 2016-11-04

Article Type : Research Paper

Abstract :Objectives. Resistant hypertension has unfavourable effects on cardiovascular and other systems. The aim of this study was to investigate the association of neutrophil/lymphocyte insert ignore into journalissuearticles values(N/L); ratio and resistant hypertension. Methods. A total of 140 patients were included in the study. Ambulatory 24-hour blood pressure monitoring, transthoracic echocardiography and blood sample analyzing were performed in all patients. There were 60 patients with resistant hypertension group insert ignore into journalissuearticles values(mean age=55.1±9.7 years); and 80 patients with non-resistant hypertension group insert ignore into journalissuearticles values(mean age=56.8±14.1 years);. Results. Mean neutrophil levels were significantly higher in resistant hypertension group insert ignore into journalissuearticles values(71.7±6.1% vs. 65.9±5.4%, p <0.001);, while lymphocyte levels were significantly higher in non-resistant hypertension group insert ignore into journalissuearticles values(22±4.7% vs. 17.5±4.1%, p <0.001);. N/L ratio was significantly higher in resistant hypertension group insert ignore into journalissuearticles values(4.3±1.2 vs. 3.1±0.9, p <0.001);. In multivariate analysis, diabetes mellitus insert ignore into journalissuearticles values(odds ratio [OR]=2.857; 95% confidence interval [CI], 1.349-6.053; p =0.006);, N/L ratio insert ignore into journalissuearticles values(OR=2.699; 95% CI, 1.821-4.002; p <0.001); and obesity insert ignore into journalissuearticles values(OR=3.429; 95% CI, 1.675-7.019; p =0.001); were independent predictors of resistant hypertension. Conclusion. The N/L ratio, which is cheaply and easily measurable laboratory data, is independently associated with resistant hypertension. 
Keywords : Resistant hypertension, ambulatory blood pressure monitoring, neutrophil lymphocyte ratio