Incidence and risk factors of contrast-induced nephropathy after diagnostic or interventional coronary angiography

Authors : Hasan ARİ, Selvi OZTAS COSAR, Selma ARİ, Kubra Doganay, Cihan AYDİN, Nadir EMLEK, Nuran CELİLOGLU, Ahmet Seckin CETİNKAYA, Tahsin BOZAT, Mehmet MELEK

Pages : 16-24

Doi:10.18621/eurj.2016.5000200322

View : 19 | Download : 9

Publication Date : 2017-03-04

Article Type : Research Paper

Abstract :Objectives. Contrast-induced nephropathy insert ignore into journalissuearticles values(CIN); is the third most common cause of acute renal failure that occurred in the hospital. In Turkey, there is not enough data about the frequency of CIN in cardiological interventions. Increased contrast volume and creatinin value are related with CIN. We also investigated the CIN predictors. Methods. A total of 2604 patients who underwent coronary angiography or percutaneous coronary intervention insert ignore into journalissuearticles values(PCI); in our hospital were prospectively evaluated in terms of CIN. The definition of CIN includes absolute insert ignore into journalissuearticles values(≥0.5mg/dl); or relative increase insert ignore into journalissuearticles values(≥25%); in serum creatinine at 48-72 h after exposure to a contrast agent compared to baseline serum creatinine values. Results. CIN was detected in 13.6% insert ignore into journalissuearticles values(355 patients); of 2604 patients. According to the procedure; CIN rate was 13.3% insert ignore into journalissuearticles values(280 of 2108 patients); in coronary angiography, 13.08% insert ignore into journalissuearticles values(50 of 382 patients); in elective PCI and 21.49% insert ignore into journalissuearticles values(25 of 114 patients); in primary PCI. Compared with each of these three groups patients, CIN rate was significantly higher in primary PCI group than coronary angiography insert ignore into journalissuearticles values( p =0.009); and elective PCI insert ignore into journalissuearticles values( p =0.02); groups. In multivariate analysis, age insert ignore into journalissuearticles values(odds ratio [OR]=1.04; 95% confidence interval [CI], 1.02-1.06; p <0.001);, glomerular filtration rate insert ignore into journalissuearticles values(OR=0.99; 95% CI, 0.98-0.99; p <0.001);, contrast volume insert ignore into journalissuearticles values(OR=1.14; 95% CI, 1.007-1.21; p <0.006);, contrast volume to creatinine ratio insert ignore into journalissuearticles values(OR=1.01; 95% CI, 1.009-1.02; p <0.001);, three vessel disease insert ignore into journalissuearticles values(OR=1.77, 95% CI, 1.24-2.51; p =0.001); were independent predictors of CIN. Conclusions. In our patient population, the incidence of CIN was found to be 13.6% in cardiological interventions. In emergency interventions, incidence of CIN was increased. We found that contrast volume to creatinine ratio is predictor of CIN. 
Keywords : Contrast induced nephropathy, coronary angiography, percutaneous coronary intervention, renal failure, contrast media