Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer

Authors : Ayca ANT, Erdogan INAL, Aslihan AVCİ, Metin GENC, Umit TUNCEL, Ziya SENCAN, Yasemin GENC

Pages : 38-43

Doi:10.18621/eurj.322520

View : 48 | Download : 16

Publication Date : 2018-01-04

Article Type : Research Paper

Abstract :Inflammation and oxidative stress are considered as the main pathways in oral cavity carcinoma . The aim of this study was to evaluate the activity levels of adenosine deaminase insert ignore into journalissuearticles values(ADA);, nitric oxide insert ignore into journalissuearticles values(NO);, nitric oxide synthase insert ignore into journalissuearticles values(NOS);, and xanthine oxidase insert ignore into journalissuearticles values(XO); in oral cavity carcinoma, to determine their potential roles in carcinogenesis with relation to oxidative stress. Methods. Seventeen patients with oral cavity cancer underwent surgery as the primary therapy, were consisted in the study. Resected oral cavity carcinoma tissues were compared with the adjacent tumor-free control tissues of the same patients; ADA, NO, NOS, XO activity levels were evaluated in terms of difference. Results. There is a significant increase of ADA activity in squamous cell cancer tissues, which indicates a difference between the normal and tumor tissues at enzyme levels insert ignore into journalissuearticles values(p<0.001);. Conclusion. Elevated ADA activity might be an attempt to supress formation of the immunosupressed niche which promotes the onset of neoplasia and/or to inhibit tumor progression and metastasis. 
Keywords : Adenosine deaminase, nitric oxide, nitric oxide synthase, oral cancer, oxidative stress, xanthine oxidase

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