The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity

Authors : Betül Sargın, Ayla Akbal, Hatice Resorlu, Yılmaz Savaş, Coşkun Zateri, Fatma Sılan, Öztürk Özdemir

Pages : 106-111

Doi:10.18621/eurj.346968

View : 24 | Download : 11

Publication Date : 2018-04-04

Article Type : Research Paper

Abstract :Objectives. We aimed to evaluate the frequency of toll-like receptor 4 insert ignore into journalissuearticles values( TLR4); gene polymorphism and its relationship between disease activity in patients with ankylosing spondylitis insert ignore into journalissuearticles values(AS);. Methods. Forty-one AS patients insert ignore into journalissuearticles values(25 male/16 female); fullfilling the 1984 Modified New York Criteria and 41 healthy controls insert ignore into journalissuearticles values( 25 male/16 female); were included in this study. Disease activity of the AS patients was assesed by Bath Ankylosing Spondylitis Disease Activity Index insert ignore into journalissuearticles values(BASDAI);. The TLR4 gene polymorphism of AS patients and healthy controls were analyzed by Real-Time Polymerase Chain Reaction insert ignore into journalissuearticles values(PCR); System. Results. Three insert ignore into journalissuearticles values(7.3%); patients with AS had TLR4 gene polymorphism compared with healthy controls insert ignore into journalissuearticles values(0/41; 0%);. Two of these patients had heterozygous mutation and one had homozygous mutation. Significant correlation was not found between TLR4 gene polymorphism and BASDAI score insert ignore into journalissuearticles values( p > 0.05);. Conclusions. In our study, TLR4 gene polymorphism was higher in patients with AS compared with control group. But, this polymorphism was not associated with disease activity, erythrocyte sedimentation rate and C-reactive protein levels. 
Keywords : Ankylosing spondylitis, disease activity, mutation, polymorphism, toll like receptor 4