Effectiveness of trospium chloride and doxazosin mesylate combination in neurogenic bladder patients with spinal cord injury

Authors : Fazıl KULAKLI, Kurtuluş KÖKLÜ, Murat ERSÖZ, Zuhal ÖZİŞLER, Canan ÇULHA, Sumru ÖZEL

Pages : 157-161

Doi:10.18621/eurj.349418

View : 17 | Download : 15

Publication Date : 2018-07-04

Article Type : Research Paper

Abstract :Objective. The aim of this study was to compare the effects of trospium chloride insert ignore into journalissuearticles values(TCL); and TCL + doxazosin insert ignore into journalissuearticles values(DXZ); combination to bladder capacity and residual urine volume insert ignore into journalissuearticles values(RUV); in spinal cord injury insert ignore into journalissuearticles values(SCI); patients with neurogenic bladder. Methods. The study included 120 patients with SCI. Urodynamic data of patients were reviewed retrospectively. Changes in maximum cystometric capacity insert ignore into journalissuearticles values(MCC); as well as RUV were determined in patients using 60-90 mg/day TCL insert ignore into journalissuearticles values(Group 1, n = 98); or 60-90 mg/day TCL + 4-6 mg/day DXZ insert ignore into journalissuearticles values(Group 2, n = 22);. Results. There was statistically significant increase in both MCC and RUV values in both groups. There was no statistical difference in MCC and RUV values in Group 1 and Group 2 insert ignore into journalissuearticles values( p = 0.111 and p = 0.664, respectively);. There was a significant weak negative correlation between duration of injury and MCC values insert ignore into journalissuearticles values(r = 0.185; p = 0.043);, meaning as the duration of injury increased, MCC decreased. There was no statistically significant correlation between medication usage duration with MCC and RUV insert ignore into journalissuearticles values(r = -0.129; p = 0.159 and r = -0.68; p = 0.462, respectively);. Conclusions. Anticholinergic treatment is currently the mainstay conservative treatment of neurogenic detrusor overactivity. The impact of alfa blockers on neurogenic bladder has been less well evaluated. We consider that, adding DXZ to TCL has no additional benefit to increase bladder capacity and reduce RUV. Further studies are needed to determine the location of DXZ treatment in SCI patients with neurogenic bladder. 
Keywords : spinal cord injury, neurogenic bladder, doksazosin mesylate, trospium chloride