Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Authors : Oğuz EROĞLU, Nermin DİNDAR BADEM, Ayşe BACCIOĞLU, Ertan CÖMERTPAY, Salim NEŞELİOĞLU, Özcan EREL

Pages : 250-257

Doi:10.18621/eurj.425178

View : 22 | Download : 11

Publication Date : 2019-03-04

Article Type : Research Paper

Abstract :Objectives:  The severity of inflammation occurring during chronic obstructive pulmonary disease insert ignore into journalissuearticles values(COPD); is closely associated with oxidative stress. The aim of this study was to investigate the diagnostic value of Thiol/disulphide homeostasis insert ignore into journalissuearticles values(TDH); and ischemia modified albumin insert ignore into journalissuearticles values(IMA); levels in evaluating oxidative stress in COPD patients. Methods:  This prospective study was performed with COPD patients presenting to the Kırıkkale University Hospital and with healthy volunteers. Subjects’ demographic data insert ignore into journalissuearticles values(age, sex, body mass index, and smoking status);, native thiol insert ignore into journalissuearticles values(NT);, total thiol insert ignore into journalissuearticles values(TT);, disulphide insert ignore into journalissuearticles values(Ds);, IMA levels and Ds/NT, Ds/TT and NT/TT ratios were recorded. Statistical analysis was performed with SPSS 21.0 software. Results:  One hundred ninety subjects were enrolled in the study, 141 COPD patients and 49 healthy volunteers. No difference was determined between the patient and control groups in terms of age, sex or body mass index. The antioxidant markers; NT and TT levels and NT/TT ratio were significantly lower in the patient group compared to the control group insert ignore into journalissuearticles values( p < 0.001, p < 0.001, and p < 0.003, respectively);. The oxidant markers; IMA levels and Ds/NT and Ds/TT ratios were significantly higher in the patient group insert ignore into journalissuearticles values( p = 0.006, p = 0.003, and p = 0.003, respectively);. Significant negative correlation was determined between antioxidant and oxidant parameters. Sensitivity values were NT: 87.2%, TT: 83.3%, Ds/NT ratio: 68.1%, Ds/TT ratio: 68.1%, and IMA: 77.8%. Conclusions:   TDH was impaired in favor oxidants in COPD patients. TDH parameters and IMA can be used to monitor oxidative stress emerging in COPD. 
Keywords : Chronic obstructive pulmonary disease, oxidative stress, thiol disulphide homeostasis, ischemia modified albumin