The alteration of first trimester screening markers in fresh and frozen-thawed blastocyst transfers

Authors : Nur Dokuzeylül Güngör, Tuğba Gürbüz, Ayşe Filiz Gökmen Karasu, Aynur Erşahin

Pages : 686-690

Doi:10.18621/eurj.400462

View : 16 | Download : 11

Publication Date : 2019-07-04

Article Type : Research Paper

Abstract :Objective: The aim of this study was to investigate whether first trimester combined screening for major fetal trisomies is influenced by assisted reproduction techniques insert ignore into journalissuearticles values(ART); from blastocyst transfer, with or without cryopreservation. Methods: This study is a retrospective analysis involving 115 singleton pregnancies with euploid fetuses recruited between January 2017 and December 2017. Sixty-five women conceived with fresh blastocysts from in vitro fertilization insert ignore into journalissuearticles values(IVF); cycles insert ignore into journalissuearticles values(fresh-blasto);, 50 with frozen-thawed blastocysts. All cases underwent ultrasound assessment at 11+0 - 13+6 weeks with measurements of crown rump length, nuchal translucency insert ignore into journalissuearticles values(NT); , free beta-human chorionic gonadotrophin insert ignore into journalissuearticles values(free β-hCG); and pregnancy-associated plasma protein A insert ignore into journalissuearticles values(PAPP-A); concentrations. Results: Baseline characteristics and pregnancy outcomes did not differ substantially among the study groups. The NT was not significantly different in the frozen-thawed -blasto compared to the fresh-blasto group insert ignore into journalissuearticles values( p = 0.741);. The free β-hCG levels was not significantly different in frozen-thawed-blasto group compared to fresh-blasto group insert ignore into journalissuearticles values( p = 0.495);. The two groups showed no significant difference in the PAPP-A levels insert ignore into journalissuearticles values( p = 0.139);. The median delta crown rump length was also not significantly different among the two groups insert ignore into journalissuearticles values( p = 0.758);. Conclusions: In ART pregnancies from blastocyst transfer, with or without cryopreservation, the NT measurement, free β-hCG concentration and PAPP-A levels did not show any significant difference. These features are apparently unrelated to the outcome of pregnancy and may be due to alterations or delays in embryogenesis or placentation with potential relevance for the screening test performance. 
Keywords : Assisted reproductive technique, blastocyst, first trimester screening, frozen thawed embryo transfer, fresh embryo transfer